发明授权
US07682607B2 Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
失效
Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标
- 专利标题： Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
- 专利标题（中）： Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标
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申请号： US10381636申请日： 2002-05-01
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公开(公告)号： US07682607B2公开(公告)日： 2010-03-23
- 发明人: Chae-Seo Rhee , Malini Sen , Christina Wu , Lorenzo M. Leoni , Maripat Corr , Dennis A. Carson
- 申请人： Chae-Seo Rhee , Malini Sen , Christina Wu , Lorenzo M. Leoni , Maripat Corr , Dennis A. Carson
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 代理机构： McDermott Will & Emery LLP
- 国际申请： PCT/US02/13802 WO 20020501
- 国际公布： WO02/088081 WO 20021107
- 主分类号： A61K39/395
- IPC分类号： A61K39/395
摘要：
The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the growth and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, The Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.
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