Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
    1.
    发明授权
    Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas 有权
    Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标

    公开(公告)号:US07713526B2

    公开(公告)日:2010-05-11

    申请号:US10285976

    申请日:2002-11-01

    IPC分类号: A61K39/395

    摘要: The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the proliferation and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, the Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.

    摘要翻译: Wnt和卷曲(Fzd)家族的多种受体 - 配体对在胚胎发育过程中起重要作用,因此可能在由未成熟细胞产生的癌症中过表达。 研究了10个头颈鳞癌细胞系(HNSCC)中5个Wnt(Wnt-1,5a,7a,10b,13)和2个Fzd(Fzd-2,5)基因的mRNA水平和表达水平。 此外,使用抗Wnt-1抗体研究Wnt / Fzd信号通路。 这些结果表明,HNSCC细胞系过表达一个或多个Wnt和Fzd基因,HNSCC亚型的增殖和存活可能取决于Wnt / Fzd途径。 因此,Wnt和Fzd受体可能是这种常见癌症的免疫治疗的有用靶标。

    Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas
    2.
    发明授权
    Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas 失效
    Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标

    公开(公告)号:US07682607B2

    公开(公告)日:2010-03-23

    申请号:US10381636

    申请日:2002-05-01

    IPC分类号: A61K39/395

    摘要: The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the growth and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, The Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.

    摘要翻译: Wnt和卷曲(Fzd)家族的多种受体 - 配体对在胚胎发育过程中起重要作用,因此可能在由未成熟细胞产生的癌症中过表达。 研究了10个头颈鳞癌细胞系(HNSCC)中5个Wnt(Wnt-1,5a,7a,10b,13)和2个Fzd(Fzd-2,5)基因的mRNA水平和表达水平。 此外,使用抗Wnt-1抗体研究Wnt / Fzd信号通路。 这些结果表明,HNSCC细胞系过表达一个或多个Wnt和Fzd基因,HNSCC亚型的生长和存活可能取决于Wnt / Fzd途径。 因此,Wnt和Fzd受体可能是这种常见癌症的免疫治疗的有用靶标。