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1.发明授权Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas 有权Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标公开(公告)号：US07713526B2
公开(公告)日：2010-05-11
申请号：US10285976
申请日：2002-11-01
申请人： Chae-Seo Rhee , Malini Sen , Christina Wu , Lorenzo M. Leoni , Maripat Corr , Dennis A. Carson
发明人： Chae-Seo Rhee , Malini Sen , Christina Wu , Lorenzo M. Leoni , Maripat Corr , Dennis A. Carson
IPC分类号： A61K39/395
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/22 , C07K16/3015 , C07K16/3023 , C07K16/3061 , C07K2317/73 , C12Q1/6851 , C12Q1/6886 , C12Q2600/158
摘要： The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the proliferation and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, the Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.
摘要翻译： Wnt和卷曲（Fzd）家族的多种受体 - 配体对在胚胎发育过程中起重要作用，因此可能在由未成熟细胞产生的癌症中过表达。 研究了10个头颈鳞癌细胞系（HNSCC）中5个Wnt（Wnt-1,5a，7a，10b，13）和2个Fzd（Fzd-2,5）基因的mRNA水平和表达水平。 此外，使用抗Wnt-1抗体研究Wnt / Fzd信号通路。 这些结果表明，HNSCC细胞系过表达一个或多个Wnt和Fzd基因，HNSCC亚型的增殖和存活可能取决于Wnt / Fzd途径。 因此，Wnt和Fzd受体可能是这种常见癌症的免疫治疗的有用靶标。
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2.发明授权Wnt and frizzled receptors as targets for immunotherapy in head and neck squamous cell carcinomas 失效Wnt和卷曲受体作为头颈部鳞状细胞癌免疫治疗的靶标公开(公告)号：US07682607B2
公开(公告)日：2010-03-23
申请号：US10381636
申请日：2002-05-01
申请人： Chae-Seo Rhee , Malini Sen , Christina Wu , Lorenzo M. Leoni , Maripat Corr , Dennis A. Carson
发明人： Chae-Seo Rhee , Malini Sen , Christina Wu , Lorenzo M. Leoni , Maripat Corr , Dennis A. Carson
IPC分类号： A61K39/395
CPC分类号： C07K16/28 , C12Q1/6851 , C12Q1/6886 , C12Q2600/158
摘要： The diverse receptor-ligand pairs of the Wnt and frizzled (Fzd) families play important roles during embryonic development, and thus may be overexpressed in cancers that arise from immature cells. The mRNA levels and expression levels of 5 Wnt (Wnt-1, 5a, 7a, 10b, 13) and 2 Fzd (Fzd-2, 5) genes in 10 head and neck squamous carcinoma cell lines (HNSCC) were investigated. In addition, anti-Wnt-1 antibodies were used to study the Wnt/Fzd signalling pathway. These results indicate that HNSCC cell lines overexpress one or more Wnt and Fzd genes, and the growth and survival of a subset of HNSCC may depend on the Wnt/Fzd pathway. Therefore, The Wnt and Fzd receptors may be useful targets for immunotherapy of this common cancer.
摘要翻译： Wnt和卷曲（Fzd）家族的多种受体 - 配体对在胚胎发育过程中起重要作用，因此可能在由未成熟细胞产生的癌症中过表达。 研究了10个头颈鳞癌细胞系（HNSCC）中5个Wnt（Wnt-1,5a，7a，10b，13）和2个Fzd（Fzd-2,5）基因的mRNA水平和表达水平。 此外，使用抗Wnt-1抗体研究Wnt / Fzd信号通路。 这些结果表明，HNSCC细胞系过表达一个或多个Wnt和Fzd基因，HNSCC亚型的生长和存活可能取决于Wnt / Fzd途径。 因此，Wnt和Fzd受体可能是这种常见癌症的免疫治疗的有用靶标。
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3.发明申请Data Processing Device for Use in an Ad-Hoc Network, and Corresponding Ad-Hoc Network 失效用于Ad-Hoc网络的数据处理设备和相应的Ad-Hoc网络公开(公告)号：US20080208978A1
公开(公告)日：2008-08-28
申请号：US11660643
申请日：2005-08-17
IPC分类号： G06F15/16
CPC分类号： H04W4/00 , H04L65/1006 , H04W84/18 , H04W88/02
摘要： In one aspect, a data processing device which comprises an application for use in an ad-hoc network whereby the application is provided with a data interface to a central service for the processing of the first data is provided. A proxy instance is connected to the application via a first data connection for the exchange of the first data, while the proxy instance is connected to a plurality of additional data processing devices via the ad-hoc network for the exchange of second data. The proxy instance is adapted to generate the first data from the second data and to generate the second data from the first data, the exchange of the first data between the application and the proxy instance being carried out via the data interface.
摘要翻译： 一方面，提供了一种数据处理设备，其包括在ad-hoc网络中使用的应用，其中应用被提供有与中央服务的数据接口用于处理第一数据。 代理实例经由用于交换第一数据的第一数据连接连接到应用，而代理实例经由ad-hoc网络连接到多个附加数据处理设备，用于交换第二数据。 所述代理实例适于从所述第二数据生成所述第一数据，并且从所述第一数据生成所述第二数据，以及经由所述数据接口执行的所述应用和所述代理实例之间的所述第一数据的交换。
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4.发明授权Data processing device for use in an ad-hoc network, and corresponding ad-hoc network 失效用于自组织网络的数据处理设备，以及相应的自组织网络公开(公告)号：US07752276B2
公开(公告)日：2010-07-06
申请号：US11660643
申请日：2005-08-17
IPC分类号： G06F15/16
CPC分类号： H04W4/00 , H04L65/1006 , H04W84/18 , H04W88/02
摘要： In one aspect, a data processing device which comprises an application for use in an ad-hoc network whereby the application is provided with a data interface to a central service for the processing of the first data is provided. A proxy instance is connected to the application via a first data connection for the exchange of the first data, while the proxy instance is connected to a plurality of additional data processing devices via the ad-hoc network for the exchange of second data. The proxy instance is adapted to generate the first data from the second data and to generate the second data from the first data, the exchange of the first data between the application and the proxy instance being carried out via the data interface.
摘要翻译： 一方面，提供了一种数据处理设备，其包括在ad-hoc网络中使用的应用，其中应用被提供有与中央服务的数据接口用于处理第一数据。 代理实例经由用于交换第一数据的第一数据连接连接到应用，而代理实例经由ad-hoc网络连接到多个附加数据处理设备，用于交换第二数据。 所述代理实例适于从所述第二数据生成所述第一数据，并且从所述第一数据生成所述第二数据，以及经由所述数据接口执行的所述应用和所述代理实例之间的所述第一数据的交换。
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