Invention Grant
US07696308B2 Recombinant protein containing a C-terminal fragment of Plasmodium MSP-1
失效
含有疟原虫MSP-1的C末端片段的重组蛋白
- Patent Title: Recombinant protein containing a C-terminal fragment of Plasmodium MSP-1
- Patent Title (中): 含有疟原虫MSP-1的C末端片段的重组蛋白
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Application No.: US11144833Application Date: 2005-06-06
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Publication No.: US07696308B2Publication Date: 2010-04-13
- Inventor: Shirley Longacre-Andre , Charles Roth , Faridabano Nato , John W. Barnwell , Kamini Mendis
- Applicant: Shirley Longacre-Andre , Charles Roth , Faridabano Nato , John W. Barnwell , Kamini Mendis
- Applicant Address: FR Paris US NY New York
- Assignee: Institut Pasteur,New York University
- Current Assignee: Institut Pasteur,New York University
- Current Assignee Address: FR Paris US NY New York
- Agency: Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- Priority: FR9601822 19960214
- Main IPC: A61K38/00
- IPC: A61K38/00 ; A01N63/00 ; C07H21/00

Abstract:
The invention relates to a recombinant protein fabricated in a baculovirus system, of which the essential constitutive polypeptide sequence is that of a C-terminal fragment of 19 kilodalton (p19) of the surface protein 1 (protein MSP-1) of the merozoite parasite of the Plasmodium type, particularly Plasmodium falciparum, which is infectious for humans, said C-terminal fragment remaining normally anchored at the surface of the parasite at the end of its penetration phase into human erythrocytes, in the occurrence of an infectious cycle. Said recombinant protein is applicable to the production of vaccines against malaria.
Public/Granted literature
- US20060018932A1 Recombinant protein containing a C-terminal fragment of Plasmodium MSP-1 Public/Granted day:2006-01-26
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