发明授权
US07709252B2 Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
有权
包括FV分子的抗体和对间皮素具有高结合亲和力的免疫缀合物及其使用方法
- 专利标题： Antibodies, including FV molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use
- 专利标题（中）： 包括FV分子的抗体和对间皮素具有高结合亲和力的免疫缀合物及其使用方法
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申请号： US12055145申请日： 2008-03-25
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公开(公告)号： US07709252B2公开(公告)日： 2010-05-04
- 发明人: Ira H. Pastan , Partha S. Chowdhury
- 申请人： Ira H. Pastan , Partha S. Chowdhury
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Townsend and Townsend and Crew LLP
- 主分类号： C12N15/00
- IPC分类号： C12N15/00
摘要：
Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas and several other types of human cancers. Because among normal tissues, mesothelin is only present on mesothelial cells, it represents a good target for antibody mediated delivery of cytotoxic agents. The present invention is directed to anti-mesothelin antibodies, including Fv molecules with particularly high affinity for mesothelin, and immunoconjugates employing them. Also described are diagnostic and therapeutic methods using the antibodies. The anti-mesothelin antibodies are well-suited for the diagnosis and treatment of cancers of the ovary, stomach, squamous cells, mesotheliomas and other malignant cells expressing mesothelin.
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