发明授权
US07718763B2 Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13
有权
von Willebrand因子切割蛋白酶ADAMTS-13的底物多肽
- 专利标题： Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13
- 专利标题（中）： von Willebrand因子切割蛋白酶ADAMTS-13的底物多肽
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申请号： US10531427申请日： 2002-10-18
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公开(公告)号： US07718763B2公开(公告)日： 2010-05-18
- 发明人: Toshiyuki Miyata , Koichi Kokame
- 申请人： Toshiyuki Miyata , Koichi Kokame
- 申请人地址： JP Suita-Shi, Osaka
- 专利权人： Japan as Represented by the President of National Cardiovascular Center
- 当前专利权人： Japan as Represented by the President of National Cardiovascular Center
- 当前专利权人地址： JP Suita-Shi, Osaka
- 代理机构： Birch, Stewart, Kolasch & Birch, LLP
- 国际申请： PCT/JP02/10816 WO 20021018
- 国际公布： WO2004/035778 WO 20040429
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A01N37/18 ; C08H1/00 ; C12P21/04
摘要：
The present invention relates to specific substrates for a von Willebrand factor cleaving enzyme, ADAMTS-13, as well as to diagnosis of ADAMTS-13 deficient patients, diagnostic compositions, and kits employing the substrates. Particularly preferable substrate polypeptides for ADAMTS-13 are the polypeptide which begins at amino acid 1587 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing, and the polypeptide which begins at amino acid 1596 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing. These substrate polypeptides for ADAMTS-13 have high substrate specificity and also superior quantitativeness, and a suitable size for production by recombinant methods.
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