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1.发明申请Substrates specific to von willebrand factor cleaving protease and method of assaying the activity 有权特异于von willebrand因子切割蛋白酶的底物和测定活性的方法公开(公告)号：US20070065895A1
公开(公告)日：2007-03-22
申请号：US10531427
申请日：2002-10-18
申请人： Toshiyuki Miyata , Koichi Kokame
发明人： Toshiyuki Miyata , Koichi Kokame
IPC分类号： C12Q1/37 , C07K14/745
CPC分类号： C12N9/6489 , C07K14/755 , C12Q1/37
摘要： The present invention relates to specific substrates for a von Willebrand factor cleaving enzyme, ADAMTS-13, as well as to diagnosis of ADAMTS-13 deficient patients, diagnostic compositions, and kits employing the substrates. Particularly preferable substrate polypeptides for ADAMTS-13 are the polypeptide which begins at amino acid 1587 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing, and the polypeptide which begins at amino acid 1596 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing. These substrate polypeptides for ADAMTS-13 have high substrate specificity and also superior quantitativeness, and a suitable size for production by recombinant methods.
摘要翻译： 本发明涉及von Willebrand因子切割酶，ADAMTS-13的特异性底物，以及ADAMTS-13缺陷患者的诊断，诊断组合物和使用该底物的试剂盒。 用于ADAMTS-13的特别优选的底物多肽是从序列表中SEQ ID NO：1的氨基酸1587开始并结束于SEQ ID NO：1的氨基酸1668的多肽，以及在氨基酸1596开始并以氨基酸1668结束的多肽 序列表中的SEQ ID NO：1。 用于ADAMTS-13的这些底物多肽具有高底物特异性，并且还具有优异的定量性，以及通过重组方法生产的合适尺寸。
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2.发明授权Substrate polyeptides for von Willebrand factor cleaving protease ADAMTS-13 有权von Willebrand因子切割蛋白酶ADAMTS-13的底物多肽公开(公告)号：US07718763B2
公开(公告)日：2010-05-18
申请号：US10531427
申请日：2002-10-18
申请人： Toshiyuki Miyata , Koichi Kokame
发明人： Toshiyuki Miyata , Koichi Kokame
CPC分类号： C12N9/6489 , C07K14/755 , C12Q1/37
摘要： The present invention relates to specific substrates for a von Willebrand factor cleaving enzyme, ADAMTS-13, as well as to diagnosis of ADAMTS-13 deficient patients, diagnostic compositions, and kits employing the substrates. Particularly preferable substrate polypeptides for ADAMTS-13 are the polypeptide which begins at amino acid 1587 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing, and the polypeptide which begins at amino acid 1596 and ends at amino acid 1668 of SEQ ID NO: 1 in the Sequence Listing. These substrate polypeptides for ADAMTS-13 have high substrate specificity and also superior quantitativeness, and a suitable size for production by recombinant methods.
摘要翻译： 本发明涉及von Willebrand因子切割酶，ADAMTS-13的特异性底物，以及ADAMTS-13缺陷患者的诊断，诊断组合物和使用该底物的试剂盒。 用于ADAMTS-13的特别优选的底物多肽是从序列表中SEQ ID NO：1的氨基酸1587开始并结束于SEQ ID NO：1的氨基酸1668的多肽，以及在氨基酸1596开始并以氨基酸1668结束的多肽 序列表中的SEQ ID NO：1。 用于ADAMTS-13的这些底物多肽具有高底物特异性，并且还具有优异的定量性，以及通过重组方法生产的合适尺寸。
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