发明授权
US07723046B2 Method of screening for a compound using guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37
失效
使用三磷酸鸟苷（GTP） - 结合蛋白偶联受体蛋白BG37筛选化合物的方法
- 专利标题： Method of screening for a compound using guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37
- 专利标题（中）： 使用三磷酸鸟苷（GTP） - 结合蛋白偶联受体蛋白BG37筛选化合物的方法
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申请号： US11704546申请日： 2007-02-08
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公开(公告)号： US07723046B2公开(公告)日： 2010-05-25
- 发明人: Takaharu Maruyama , Takao Nakamura , Haraku Itadani , Ken-ichi Tanaka
- 申请人： Takaharu Maruyama , Takao Nakamura , Haraku Itadani , Ken-ichi Tanaka
- 申请人地址： JP Tokyo
- 专利权人： Banyu Pharmaceutical Co., Ltd.
- 当前专利权人： Banyu Pharmaceutical Co., Ltd.
- 当前专利权人地址： JP Tokyo
- 代理商 John D. Reilly; John C. Todaro
- 优先权： JP2000-351741 20001117; JP2001-38619 20010215; JP2001-77000 20010316
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C07K14/00
摘要：
The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”. cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the “BG37” receptor.