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    Method of screening for a compound using guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37
    1.
    发明授权
    Method of screening for a compound using guanosine triphosphate (GTP)-binding protein-coupled receptor protein, BG37 失效
    使用三磷酸鸟苷（GTP） - 结合蛋白偶联受体蛋白BG37筛选化合物的方法

    公开(公告)号：US07723046B2

    公开(公告)日：2010-05-25

    申请号：US11704546

    申请日：2007-02-08

    申请人： Takaharu Maruyama ,  Takao Nakamura ,  Haraku Itadani ,  Ken-ichi Tanaka

    发明人： Takaharu Maruyama ,  Takao Nakamura ,  Haraku Itadani ,  Ken-ichi Tanaka

    IPC分类号： G01N33/53 ,  C07K14/00

    CPC分类号： C07K14/705

    摘要： The present inventors conducted a similarity search of the amino acid sequence of known G protein-coupled receptor proteins in GenBank, and obtained a novel human GPCR gene “BG37”. cDNA containing the ORF of the gene was cloned and its nucleotide sequence was determined. Moreover, novel GPCR “BG37” genes from mouse and rat were isolated. Use of the novel GPCR of the present invention enables screening of ligands, compounds inhibiting the binding to a ligand, and candidate compounds of pharmaceuticals which can regulate signal transduction from the “BG37” receptor.

    摘要翻译： 本发明人对GenBank中已知的G蛋白偶联受体蛋白质的氨基酸序列进行了相似检索，得到了新的人GPCR基因“BG37”。 克隆含有该基因ORF的cDNA，测定其核苷酸序列。 此外，分离了来自小鼠和大鼠的新型GPCR“BG37”基因。 使用本发明的新型GPCR能够筛选配体，抑制与配体结合的化合物，以及可调节从“BG37”受体的信号转导的药物的候选化合物。