发明授权
- 专利标题： Method for screening an agent that modulates activity of macrophage migration inhibitory factor
- 专利标题（中）： 筛选调节巨噬细胞迁移抑制因子活性的试剂的方法
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申请号： US11182241申请日： 2005-07-15
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公开(公告)号： US07732146B2公开(公告)日： 2010-06-08
- 发明人: Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
- 申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
- 申请人地址： US CA Aliso Viejo
- 专利权人： Avanir Pharmaceuticals
- 当前专利权人： Avanir Pharmaceuticals
- 当前专利权人地址： US CA Aliso Viejo
- 代理机构： Knobbe Martens Olson & Bear LLP
- 主分类号： G01N33/53
- IPC分类号： G01N33/53 ; C12N5/00 ; C07K16/24 ; C07K14/52
摘要：
Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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