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1.发明授权Method for screening an agent that modulates activity of macrophage migration inhibitory factor 失效筛选调节巨噬细胞迁移抑制因子活性的试剂的方法公开(公告)号：US07732146B2
公开(公告)日：2010-06-08
申请号：US11182241
申请日：2005-07-15
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
摘要翻译： 提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 2，R 3，R 4，X，Y和Z如本文所定义。 还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。
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2.发明授权公开(公告)号：US07192955B2
公开(公告)日：2007-03-20
申请号：US11415785
申请日：2006-05-02
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
IPC分类号： A61K31/551 , C07D401/04
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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3.发明授权公开(公告)号：US07235565B2
公开(公告)日：2007-06-26
申请号：US11415552
申请日：2006-05-02
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
IPC分类号： A61K31/4709 , C07D401/04
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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4.发明授权公开(公告)号：US07129236B2
公开(公告)日：2006-10-31
申请号：US11415998
申请日：2006-05-02
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K.C.
IPC分类号： A61K31/551 , C07D401/02
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
摘要翻译： 提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 2，R 3， >，R 4，X，Y和Z如本文所定义。 还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。
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5.发明授权公开(公告)号：US07435737B2
公开(公告)日：2008-10-14
申请号：US11635319
申请日：2006-12-07
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
IPC分类号： A61K31/496
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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公开(公告)号：US07238809B2
公开(公告)日：2007-07-03
申请号：US11415842
申请日：2006-05-02
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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7.发明授权Process for the preparation of inhibitors of macrophage migration inhibitory factor 失效制备巨噬细胞迁移抑制因子抑制剂的方法公开(公告)号：US07230106B2
公开(公告)日：2007-06-12
申请号：US11416165
申请日：2006-05-02
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
IPC分类号： C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
摘要翻译： 提供了MIF的抑制剂，其可用于治疗各种疾病，包括治疗与MIF活性相关的病理状况。 MIF的抑制剂具有以下结构：包括其立体异构体，前药和药学上可接受的盐，其中n，R 1，R 2，R 3， >，R 4，X，Y和Z如本文所定义。 还提供了含有与药学上可接受的载体组合的MIF抑制剂的组合物，以及使用该组合物的方法。
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8.发明授权公开(公告)号：US07192961B2
公开(公告)日：2007-03-20
申请号：US11415628
申请日：2006-05-02
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
IPC分类号： A61K31/496
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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9.发明授权公开(公告)号：US07105519B2
公开(公告)日：2006-09-12
申请号：US10156650
申请日：2002-05-24
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Mumar K. C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Mumar K. C.
IPC分类号： A61K31/496 , C07D403/04 , C07D405/14 , C07D409/14
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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10.发明授权公开(公告)号：US07157469B2
公开(公告)日：2007-01-02
申请号：US11416004
申请日：2006-05-02
申请人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
发明人： Federico C. A. Gaeta , Andrew Baird , Jerry Anchin , Wenbin Ying , Robert Florkiewicz , Jagadish Sircar , Sunil Kumar K. C.
IPC分类号： A61K31/4709 , C07D401/02
CPC分类号： C07D401/12 , C07D215/42 , C07D215/54 , C07D405/12 , C07D409/12
摘要： Inhibitors of MIF are provided which have utility in the treatment of a variety of disorders, including the treatment of pathological conditions associated with MIF activity. The inhibitors of MIF have the following structures: including stereoisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein n, R1, R2, R3, R4, X, Y and Z are as defined herein. Compositions containing an inhibitor of MIF in combination with a pharmaceutically acceptable carrier are also provided, as well as methods for use of the same.
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