发明授权
- 专利标题： Method of constructing spinal injury model monkey and utilization thereof
- 专利标题（中）： 构建脊髓损伤模型猴的方法及其应用
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申请号： US10496993申请日： 2002-11-26
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公开(公告)号： US07753054B2公开(公告)日： 2010-07-13
- 发明人: Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Tatsuji Nomura , Yoshikuni Tanioka , Kiyoshi Ando , Yonehiro Kanemura
- 申请人： Hideyuki Okano , Yoshiaki Toyama , Masaya Nakamura , Tatsuji Nomura , Yoshikuni Tanioka , Kiyoshi Ando , Yonehiro Kanemura
- 申请人地址： JP Kawaguchi-shi JP Tokyo
- 专利权人： Japan Science and Technology Agency,Keio University
- 当前专利权人： Japan Science and Technology Agency,Keio University
- 当前专利权人地址： JP Kawaguchi-shi JP Tokyo
- 代理机构： Oblon, Spivak, McClelland, Maier & Neustadt, L.L.P.
- 优先权： JP2001-364563 20011129
- 国际申请： PCT/JP02/12308 WO 20021126
- 国际公布： WO03/045137 WO 20030605
- 主分类号： A61B19/00
- IPC分类号： A61B19/00
摘要：
A method for creating a monkey model of spinal cord injury, which includes exposing the dura mater of the cervical cord of a monkey and applying a load on the dura mater; the thus-created monkey model of spinal cord injury; and a method for evaluating a therapeutic drug for spinal cord injury by use of this model.According to the present invention, it is possible to create a monkey which is close to the human and thus useful as a model of human spinal cord injury. This model enables proper evaluation of therapeutic effects of various drugs on spinal cord injury. Through use of this model, it has been confirmed for the first time that transplantation therapy of human neural stem cells is efficacious against spinal cord injury.
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