Invention Grant
- Patent Title: Analogs of benzoquinone-containing ansamycins and methods of use thereof
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Application No.: US12199356Application Date: 2008-08-27
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Publication No.: US07767662B2Publication Date: 2010-08-03
- Inventor: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
- Applicant: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
- Applicant Address: US MA Cambridge
- Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Foley Hoag LLP
- Main IPC: A61K31/395
- IPC: A61K31/395 ; A61K35/00 ; C07D225/06 ; C07D211/60 ; C07D498/08
Abstract:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
Public/Granted literature
- US20090069280A1 ANALOGS OF BENZOQUINONE-CONTAINING ANSAMYCINS AND METHODS OF USE THEREOF Public/Granted day:2009-03-12
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