Invention Grant
US07767663B2 Analogs of benzoquinone-containing ansamycins and methods of use thereof
有权
含有苯醌的安莎霉素的类似物及其使用方法
- Patent Title: Analogs of benzoquinone-containing ansamycins and methods of use thereof
- Patent Title (中): 含有苯醌的安莎霉素的类似物及其使用方法
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Application No.: US12369545Application Date: 2009-02-11
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Publication No.: US07767663B2Publication Date: 2010-08-03
- Inventor: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
- Applicant: Julian Adams , Yun Gao , Asimina T. Georges Evangelinos , Louis Grenier , Roger H. Pak , James R. Porter , James L. Wright
- Applicant Address: US MA Cambridge
- Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee: Infinity Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Foley Hoag LLP
- Main IPC: A61P35/00
- IPC: A61P35/00
Abstract:
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer. The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting 17-ammonium hydroquinone ansamycin analog.
Public/Granted literature
- US20090209549A1 Analogs of Benzoquinone-Containing Ansamycins and Methods of Use Thereof Public/Granted day:2009-08-20
Information query
IPC分类:
| A | 人类生活必需 |
| A61 | 医学或兽医学；卫生学 |
| A61P | 化合物或药物制剂的特定治疗活性 |
| A61P35/00 | 抗肿瘤药 |
