Invention Grant
US07776338B2 Adjuvant activities of mutants of LT-IIa and LT-IIb enterotoxin lacking binding to ganglioside
失效
LT-IIa和LT-IIb突变体的佐剂活性与神经节苷脂缺乏结合
- Patent Title: Adjuvant activities of mutants of LT-IIa and LT-IIb enterotoxin lacking binding to ganglioside
- Patent Title (中): LT-IIa和LT-IIb突变体的佐剂活性与神经节苷脂缺乏结合
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Application No.: US12265516Application Date: 2008-11-05
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Publication No.: US07776338B2Publication Date: 2010-08-17
- Inventor: Terry D. Connell , Michael W. Russell , Hesham Nawar , Sergio Arce
- Applicant: Terry D. Connell , Michael W. Russell , Hesham Nawar , Sergio Arce
- Applicant Address: US NY Amherst
- Assignee: The Research Foundation of State University of New York
- Current Assignee: The Research Foundation of State University of New York
- Current Assignee Address: US NY Amherst
- Agency: Hodgson Russ LLP
- Main IPC: A61K39/02
- IPC: A61K39/02 ; A61K39/00 ; A61K39/385 ; A61K39/108 ; A61K45/00 ; A61K39/116 ; A01N37/18
Abstract:
The present invention describes the adjuvant activity of mutants of LT-IIa and LT-IIb enterotoxin which lack ganglioside binding activity. The adjuvant activity of the LT-IIb(T13I) mutant is comparable to that of the wild type LT-IIb. The adjuvant activity of LT-IIa(T34I) mutant is also described which exhibits a late onset adjuvant activity. These mutants are useful for enhancing immune response to antigens.
Public/Granted literature
- US20090136535A1 ADJUVANT ACTIVITIES OF MUTANTS OF LT-IIa AND LT-IIb ENTEROTOXIN LACKING BINDING TO GANGLIOSIDE Public/Granted day:2009-05-28
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