发明授权
- 专利标题： Methods for identifying an individual at increased risk of developing coronary artery disease
- 专利标题（中）： 确定发生冠状动脉疾病风险增加的个体的方法
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申请号： US12031528申请日： 2008-02-14
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公开(公告)号： US07790390B2公开(公告)日： 2010-09-07
- 发明人: Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
- 申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
- 申请人地址： US NC Durham
- 专利权人： Duke University
- 当前专利权人： Duke University
- 当前专利权人地址： US NC Durham
- 代理机构： Myers Bigel Sibley & Sajovec, P.A.
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12P19/34 ; C07H21/02 ; C07H21/04
摘要：
The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
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