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公开(公告)号：US20130017962A1
公开(公告)日：2013-01-17
申请号：US12874635
申请日：2010-09-02
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68 , G01N27/447 , C40B30/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G16B20/00
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
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2.发明申请METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE 有权用于与心血管疾病相关的遗传标记物的方法和组合物公开(公告)号：US20110171630A1
公开(公告)日：2011-07-14
申请号：US12888937
申请日：2010-09-23
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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3.发明授权公开(公告)号：US07807465B2
公开(公告)日：2010-10-05
申请号：US11260842
申请日：2005-10-27
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon S. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon S. Gregory , William E. Kraus , Elizabeth R. Hauser
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
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4.发明申请Methods and Compositions for Correlating Genetic Markers with Cardiovascular Disease 审中-公开将遗传标记与心血管疾病相关的方法和组合公开(公告)号：US20130324416A1
公开(公告)日：2013-12-05
申请号：US13351042
申请日：2012-01-16
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G16B20/00
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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5.发明授权
公开(公告)号：US5955266A
公开(公告)日：1999-09-21
申请号：US626023
申请日：1996-04-01
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： A method for diagnosing a subject having or at risk of having a thrombotic disease syndrome by analysis of a platelet polymorphism is provided. The association between a polymorphism of the Pl.sup.A2 allele of the GPIIIa gene and unstable thrombotic syndromes provides the basis for methods and kits for diagnosing subjects.
摘要翻译： 提供了通过分析血小板多态性来诊断具有血栓性疾病综合征或具有血栓性疾病综合征风险的受试者的方法。 GPIIIa基因的PlA2等位基因的多态性与不稳定的血栓形成综合征之间的关联为诊断受试者的方法和试剂盒提供了依据。
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6.发明授权Methods for identifying an individual at increased risk of developing coronary artery disease 有权确定发生冠状动脉疾病风险增加的个体的方法公开(公告)号：US07790390B2
公开(公告)日：2010-09-07
申请号：US12031528
申请日：2008-02-14
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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7.发明授权Methods for identifying an individual at increased risk of developing coronary artery disease 有权确定发生冠状动脉疾病风险增加的个体的方法公开(公告)号：US08097415B2
公开(公告)日：2012-01-17
申请号：US12888937
申请日：2010-09-23
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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公开(公告)号：US20110287961A1
公开(公告)日：2011-11-24
申请号：US13124220
申请日：2009-10-14
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： This invention relates, e.g., to a method for screening a subject for the presence of coronary atherosclerosis, said method comprising measuring the expression level of at least 5 of the genes of Table 2 in a biological sample obtained from said subject, wherein an elevated level of expression of said 5 genes compared to a control level measured in a population of normal subjects is indicative of an increased probability of the subject having significant subclinical coronary atherosclerosis. Methods for deciding on a treatment modality, based on a diagnostic procedure of the invention, are also described, as are kits for carrying out a method of the invention.
摘要翻译： 本发明涉及例如用于筛选受试者存在冠状动脉粥样硬化的方法，所述方法包括测量从所述受试者获得的生物样品中表2的至少5个基因的表达水平，其中升高的水平 所述5种基因的表达与在正常受试者群体中测量的对照水平相比表明具有显着亚临床冠状动脉粥样硬化的受试者的概率增加。 还描述了基于本发明的诊断程序来决定治疗方式的方法，以及用于实施本发明的方法的试剂盒。
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9.发明申请METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE 有权用于与心血管疾病相关的遗传标记物的方法和组合物公开(公告)号：US20090087844A1
公开(公告)日：2009-04-02
申请号：US12031528
申请日：2008-02-14
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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