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1.发明授权Methods for identifying an individual at increased risk of developing coronary artery disease 有权确定发生冠状动脉疾病风险增加的个体的方法公开(公告)号：US07790390B2
公开(公告)日：2010-09-07
申请号：US12031528
申请日：2008-02-14
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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公开(公告)号：US20130017962A1
公开(公告)日：2013-01-17
申请号：US12874635
申请日：2010-09-02
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68 , G01N27/447 , C40B30/04
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G16B20/00
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
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3.发明申请METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE 有权用于与心血管疾病相关的遗传标记物的方法和组合物公开(公告)号：US20110171630A1
公开(公告)日：2011-07-14
申请号：US12888937
申请日：2010-09-23
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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4.发明申请Methods and Compositions for Correlating Genetic Markers with Cardiovascular Disease 审中-公开将遗传标记与心血管疾病相关的方法和组合公开(公告)号：US20130324416A1
公开(公告)日：2013-12-05
申请号：US13351042
申请日：2012-01-16
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G16B20/00
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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5.发明授权Methods for identifying an individual at increased risk of developing coronary artery disease 有权确定发生冠状动脉疾病风险增加的个体的方法公开(公告)号：US08097415B2
公开(公告)日：2012-01-17
申请号：US12888937
申请日：2010-09-23
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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6.发明申请METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH CARDIOVASCULAR DISEASE 有权用于与心血管疾病相关的遗传标记物的方法和组合物公开(公告)号：US20090087844A1
公开(公告)日：2009-04-02
申请号：US12031528
申请日：2008-02-14
申请人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
发明人： Jeffery M. Vance , Pascal J. Goldschmidt , Simon G. Gregory , William E. Kraus , Elizabeth R. Hauser
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G06F19/18
摘要： The present invention provides methods of identifying a subject having an increased or decreased risk of developing cardiovascular disease, comprising: a) correlating the presence of one or more genetic markers in chromosome 3q13.31 with an increased or decreased risk of developing cardiovascular disease; and b) detecting the one or more genetic markers of step (a) in the subject, thereby identifying the subject as having an increased or decreased risk of developing cardiovascular disease. Also provided are methods of identifying subjects with cardiovascular disease as having a good or poor prognosis, as well as methods of identifying effective treatment regimens for cardiovascular disease, based on correlation with genetic markers in chromosome 3q13.31.
摘要翻译： 本发明提供鉴定发生心血管疾病风险增加或降低的受试者的方法，其包括：a）将染色体3q13.31中的一种或多种遗传标记的存在与发生心血管疾病的风险增加或降低相关联; 和b）检测受试者中步骤（a）的一种或多种遗传标记，从而将受试者鉴定为发生心血管疾病的风险增加或降低。 还提供了基于与染色体3q13.31中的遗传标记的相关性来鉴定具有心血管疾病的受试者具有良好或不良预后的方法，以及鉴定心血管疾病的有效治疗方案的方法。
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公开(公告)号：US20180274033A1
公开(公告)日：2018-09-27
申请号：US15928939
申请日：2018-03-22
申请人： Mariano A. Garcia-Blanco , Gaddiel Galarza-Munoz , Simon G. Gregory , Farren B.S. Briggs , Lisa F. Barcellos , Shelton S. Bradrick , Irina Evsyukova , Dennis C. Ko
发明人： Mariano A. Garcia-Blanco , Gaddiel Galarza-Munoz , Simon G. Gregory , Farren B.S. Briggs , Lisa F. Barcellos , Shelton S. Bradrick , Irina Evsyukova , Dennis C. Ko
IPC分类号： C12Q1/6883 , C12Q1/34 , C12Q1/6806
CPC分类号： C12Q1/6883 , C12Q1/34 , C12Q1/6806 , C12Q1/683 , C12Q1/6851 , C12Q1/686 , C12Q2600/156 , C12Y306/04013
摘要： The present invention includes a method, kits, and assays for identifying a human subject as having an increased risk of developing an autoimmune disease, or a human subject with multiple sclerosis caused by elevated soluble Interleukin 7 receptor (sIL7R), by obtaining a biological sample and detecting or measuring in the biological sample an amount of a soluble Interleukin-7 receptor (sIL7R) and an amount of an RNA Helicase DDX39B, whereby a lower expression of DDX39B and a higher secretion of sIL7R identifies the subject from which the biological sample was obtained as having an increased risk of developing an autoimmune disease, when compared to a human subject not having an autoimmune disease. The present invention also includes a method of modifying a treating of subjects based on the lower expression of RNA Helicase DDX39B alone or in combination with an increase in sIL7R.
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8.发明授权Methods and compositions for correlating genetic markers with multiple sclerosis 失效将遗传标记与多发性硬化相关联的方法和组合物公开(公告)号：US08158344B2
公开(公告)日：2012-04-17
申请号：US12147171
申请日：2008-06-26
申请人： Jonathan L. Haines , Simon G. Gregory , Silke Schmidt , Margaret A. Pericak-Vance , Mariano Garcia-Blanco
发明人： Jonathan L. Haines , Simon G. Gregory , Silke Schmidt , Margaret A. Pericak-Vance , Mariano Garcia-Blanco
CPC分类号： G01N33/564 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N2333/7155 , G01N2800/285 , G01N2800/50
摘要： The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence of a nucleotide variant in the interleukin 7 receptor alpha chain gene, whereby the presence of said variant identifies the subject as having an increased risk of developing multiple sclerosis.
摘要翻译： 本发明在某些方面提供了鉴定受试者具有发展多发性硬化的风险增加的方法，其包括在受试者中检测白细胞介素7受体α链基因中核苷酸变体的存在，从而存在所述 变体识别受试者具有发展多发性硬化的风险增加。
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9.发明申请METHODS AND COMPOSITIONS FOR CORRELATING GENETIC MARKERS WITH MULTIPLE SCLEROSIS 失效用多种类型的SCLEROSIS相关基因标记的方法和组合公开(公告)号：US20090035778A1
公开(公告)日：2009-02-05
申请号：US12147171
申请日：2008-06-26
申请人： Jonathan L. Haines , Simon G. Gregory , Silke Schmidt , Margaret A. Pericak-Vance , Mariano Garcia-Blanco
发明人： Jonathan L. Haines , Simon G. Gregory , Silke Schmidt , Margaret A. Pericak-Vance , Mariano Garcia-Blanco
CPC分类号： G01N33/564 , C12Q1/6883 , C12Q2600/106 , C12Q2600/156 , C12Q2600/158 , C12Q2600/172 , G01N2333/7155 , G01N2800/285 , G01N2800/50
摘要： The present invention provides, in certain aspects, a method of identifying a subject as having an increased risk of developing multiple sclerosis, comprising detecting in the subject the presence of a nucleotide variant in the interleukin 7 receptor alpha chain gene, whereby the presence of said variant identifies the subject as having an increased risk of developing multiple sclerosis.
摘要翻译： 本发明在某些方面提供了鉴定受试者具有发展多发性硬化的风险增加的方法，其包括在受试者中检测白细胞介素7受体α链基因中核苷酸变体的存在，从而存在所述 变体识别受试者具有发展多发性硬化的风险增加。
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