发明授权
- 专利标题： Histone deacetylase inhibitors
- 专利标题（中）： 组蛋白脱乙酰酶抑制剂
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申请号： US11660718申请日： 2005-08-22
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公开(公告)号： US07795304B2公开(公告)日： 2010-09-14
- 发明人: Sandro Belvedere , Christopher Laurence Hamblett , Thomas A. Miller , David J. Witter , Jiaming Yan
- 申请人： Sandro Belvedere , Christopher Laurence Hamblett , Thomas A. Miller , David J. Witter , Jiaming Yan
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Li Su; David A Muthard
- 国际申请： PCT/US2005/029913 WO 20050822
- 国际公布： WO2006/026260 WO 20060309
- 主分类号： C07C271/20
- IPC分类号： C07C271/20 ; C07D295/088 ; C07D277/46 ; C07D213/30 ; A61K31/5375 ; A61K31/4402 ; A61K31/4168 ; A61K31/40 ; A61K31/325
摘要：
The invention relates to hydroxamic acid derivatives having carbamate linkage with the structural formula that are inhibitors of histone deacetylase (HDAC), and are useful in the prevention and/or treatment of cellular proliferative diseases, for example cancer, autoimmune, allergic and inflammatory diseases, diseases of the central nervous systems (CNS) such as neurodegenerative diseases, and in the prevention and/or treatment of restenosis.
公开/授权文献
- US20090118291A1 Histone deacetylase inhibitors 公开/授权日：2009-05-07
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