发明授权
- 专利标题： Inhibitors of 11-β-hydroxy steroid dehydrogenase type 1
- 专利标题（中）： 11-和β-羟基类固醇脱氢酶1型抑制剂
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申请号： US11819607申请日： 2007-06-28
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公开(公告)号： US07807700B2公开(公告)日： 2010-10-05
- 发明人: Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, Jr. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle
- 申请人： Martin Henriksson , Evert Homan , Lars Johansson , Jerk Vallgarda , Meredith Williams , Eric Bercot , Christopher H. Fotsch , Aiwen Li , Guolin Cai , Randall W. Hungate , Chester Chenguang Yuan , Christopher Tegley , David J. St. Jean, Jr. , Nianhe Han , Qi Huang , Qingyian Liu , Michael D. Bartberger , George A. Moniz , Matthew J. Frizzle
- 申请人地址： US CA Thousand Oaks
- 专利权人： Amgen Inc.
- 当前专利权人： Amgen Inc.
- 当前专利权人地址： US CA Thousand Oaks
- 代理机构： Foley & Lardner LLP
- 主分类号： A61K31/427
- IPC分类号： A61K31/427 ; C07D277/14 ; C07D277/18
摘要：
The present invention relates to compounds with the formula (I), (II), (III) or (IV): wherein R1, R2, R3, R4, R5, R6, R7, X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-β-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.
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