发明授权
US07820659B2 Cyclohexylimidiazole lactam derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase 1
有权
环己基二咪唑内酰胺衍生物作为11-＆bgr-羟基类固醇脱氢酶1的抑制剂
- 专利标题： Cyclohexylimidiazole lactam derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase 1
- 专利标题（中）： 环己基二咪唑内酰胺衍生物作为11-＆bgr-羟基类固醇脱氢酶1的抑制剂
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申请号： US12297361申请日： 2007-04-19
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公开(公告)号： US07820659B2公开(公告)日： 2010-10-26
- 发明人: Ashraf Saeed , Owen Brendan Wallace , Yanping Xu , Thomas Edward Mabry , Rebecca Lynn Rezac Guenther , Nancy June Snyder
- 申请人： Ashraf Saeed , Owen Brendan Wallace , Yanping Xu , Thomas Edward Mabry , Rebecca Lynn Rezac Guenther , Nancy June Snyder
- 申请人地址： US IN Indianapolis
- 专利权人： Eli Lilly and Company
- 当前专利权人： Eli Lilly and Company
- 当前专利权人地址： US IN Indianapolis
- 代理商 Dan L. Wood
- 国际申请： PCT/US2007/066907 WO 20070419
- 国际公布： WO2007/124329 WO 20071101
- 主分类号： A61K31/41
- IPC分类号： A61K31/41 ; A61K31/42 ; A61K31/44 ; A61K31/445 ; A61K31/497 ; A61K31/505 ; A61K31/535 ; C07D211/32 ; C07D403/02 ; C07D413/14
摘要：
The present invention discloses novel compounds of Formula I: (I) having 11β-HSD type 1 antagonist activity, as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising compounds of Formula I, as well as methods of using the compounds and compositions to treat diabetes, hyperglycemia, obesity, hypertension, hyperlipidemia, metabolic syndrome, and other conditions associated with 11β-HSD type 1 activity.
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