发明授权
US07892569B2 Methods of altering an immune response induced by CpG oligodeoxynucleotides
有权
改变由CpG寡脱氧核苷酸诱导的免疫应答的方法
- 专利标题： Methods of altering an immune response induced by CpG oligodeoxynucleotides
- 专利标题（中）： 改变由CpG寡脱氧核苷酸诱导的免疫应答的方法
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申请号： US12065085申请日： 2006-08-28
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公开(公告)号： US07892569B2公开(公告)日： 2011-02-22
- 发明人: Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
- 申请人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
- 申请人地址： US DC Washington
- 专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人： The United States of America as represented by the Department of Health and Human Services
- 当前专利权人地址： US DC Washington
- 代理机构： Klarquist Sparkman, LLP
- 国际申请： PCT/US2006/033774 WO 20060828
- 国际公布： WO2007/027718 WO 20070308
- 主分类号： A61K45/00
- IPC分类号： A61K45/00
摘要：
It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
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