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1.发明申请公开(公告)号：US20110110883A1
公开(公告)日：2011-05-12
申请号：US13005488
申请日：2011-01-12
申请人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
发明人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
IPC分类号： A61K31/7088 , A61K38/19 , A61K38/21 , A61K39/00 , A61P37/04 , A61P31/04 , A61P31/12 , A61P31/10 , A61P31/00 , A61P35/00
CPC分类号： C12N15/117 , C12N15/111 , C12N2310/17 , C12N2320/50
摘要： It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
摘要翻译： 本文公开了影响CXCL16的活性和/或表达的药剂可用于改变D型CpG寡脱氧核苷酸（D ODN）的摄取。 公开了诱导免疫应答的方法，其包括增加CXCL16和DODN的活性和/或表达的施用试剂。 还公开了降低对CpG ODN的免疫应答的方法。 这些方法包括施用降低CXCL16的活性和/或表达的试剂。 提供包含一种或多种D型ODN的组合物和调节CXCL16的活性和/或表达的试剂。
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公开(公告)号：US08580944B2
公开(公告)日：2013-11-12
申请号：US13530028
申请日：2012-06-21
IPC分类号： A61K31/70
CPC分类号： C12N15/117 , A61K31/7125 , A61K38/00 , A61K45/06 , C12N2310/18 , C12N2310/315 , C12N2310/3515
摘要： The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
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公开(公告)号：US07514414B2
公开(公告)日：2009-04-07
申请号：US10489839
申请日：2002-09-24
IPC分类号： A61K31/70
CPC分类号： C12N15/117 , A61K31/7125 , A61K38/00 , A61K45/06 , C12N2310/18 , C12N2310/315 , C12N2310/3515
摘要： The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
摘要翻译： 本公开涉及抑制免疫应答的寡脱氧核苷酸。 公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来预防或治疗免疫介导的病症，例如但不限于自身免疫性疾病的方法。 还公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来抑制受试者的免疫应答的方法。
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4.发明授权Methods of altering an immune response induced by CpG oligodeoxynucleotides 有权改变由CpG寡脱氧核苷酸诱导的免疫应答的方法公开(公告)号：US08470342B2
公开(公告)日：2013-06-25
申请号：US13005488
申请日：2011-01-12
申请人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
发明人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
CPC分类号： C12N15/117 , C12N15/111 , C12N2310/17 , C12N2320/50
摘要： It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
摘要翻译： 本文公开了影响CXCL16的活性和/或表达的药剂可用于改变D型CpG寡脱氧核苷酸（D ODN）的摄取。 公开了诱导免疫应答的方法，其包括增加CXCL16和DODN的活性和/或表达的施用试剂。 还公开了降低对CpG ODN的免疫应答的方法。 这些方法包括施用降低CXCL16的活性和/或表达的试剂。 提供包含一种或多种D型ODN的组合物和调节CXCL16的活性和/或表达的试剂。
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公开(公告)号：US20120258144A1
公开(公告)日：2012-10-11
申请号：US13530028
申请日：2012-06-21
IPC分类号： A61K31/7088 , A61P37/06 , C07H21/04
CPC分类号： C12N15/117 , A61K31/7125 , A61K38/00 , A61K45/06 , C12N2310/18 , C12N2310/315 , C12N2310/3515
摘要： The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
摘要翻译： 本公开涉及抑制免疫应答的寡脱氧核苷酸。 公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来预防或治疗免疫介导的病症，例如但不限于自身免疫性疾病的方法。 还公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来抑制受试者的免疫应答的方法。
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公开(公告)号：US08227438B2
公开(公告)日：2012-07-24
申请号：US12395539
申请日：2009-02-27
IPC分类号： A61K31/70
CPC分类号： C12N15/117 , A61K31/7125 , A61K38/00 , A61K45/06 , C12N2310/18 , C12N2310/315 , C12N2310/3515
摘要： The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
摘要翻译： 本公开涉及抑制免疫应答的寡脱氧核苷酸。 公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来预防或治疗免疫介导的病症，例如但不限于自身免疫性疾病的方法。 还公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来抑制受试者的免疫应答的方法。
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7.发明授权Methods of altering an immune response induced by CpG oligodeoxynucleotides 有权改变由CpG寡脱氧核苷酸诱导的免疫应答的方法公开(公告)号：US07892569B2
公开(公告)日：2011-02-22
申请号：US12065085
申请日：2006-08-28
申请人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
发明人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
IPC分类号： A61K45/00
CPC分类号： C12N15/117 , C12N15/111 , C12N2310/17 , C12N2320/50
摘要： It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
摘要翻译： 本文公开了影响CXCL16的活性和/或表达的药剂可用于改变D型CpG寡脱氧核苷酸（D ODN）的摄取。 公开了诱导免疫应答的方法，其包括增加CXCL16和DODN的活性和/或表达的施用试剂。 还公开了降低对CpG ODN的免疫应答的方法。 这些方法包括施用降低CXCL16的活性和/或表达的试剂。 提供包含一种或多种D型ODN的组合物和调节CXCL16的活性和/或表达的试剂。
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公开(公告)号：US20090208468A1
公开(公告)日：2009-08-20
申请号：US12395539
申请日：2009-02-27
IPC分类号： A61K35/12 , C07H21/00 , A61K31/711 , A61P35/00
CPC分类号： C12N15/117 , A61K31/7125 , A61K38/00 , A61K45/06 , C12N2310/18 , C12N2310/315 , C12N2310/3515
摘要： The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating an immune-mediated disorder, such as, but not limited to, an autoimmune disease, by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide. Also disclosed are methods of suppressing an immune response in a subject by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
摘要翻译： 本公开涉及抑制免疫应答的寡脱氧核苷酸。 公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来预防或治疗免疫介导的病症，例如但不限于自身免疫性疾病的方法。 还公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来抑制受试者的免疫应答的方法。
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9.发明申请Methods of Altering an Immune Response Induced by Cpg Oligodeoxynucleotides 有权改变Cpg寡脱氧核苷酸诱导的免疫反应的方法公开(公告)号：US20080249056A1
公开(公告)日：2008-10-09
申请号：US12065085
申请日：2006-08-28
申请人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
发明人： Dennis M. Klinman , Mayda Gursel , Ihsan Gursel
IPC分类号： A61K31/711 , C12N5/00 , G01N33/53 , C12Q1/68
CPC分类号： C12N15/117 , C12N15/111 , C12N2310/17 , C12N2320/50
摘要： It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.
摘要翻译： 本文公开了影响CXCL16的活性和/或表达的药剂可用于改变D型CpG寡脱氧核苷酸（D ODN）的摄取。 公开了诱导免疫应答的方法，其包括增加CXCL16和DODN的活性和/或表达的施用试剂。 还公开了降低对CpG ODN的免疫应答的方法。 这些方法包括施用降低CXCL16的活性和/或表达的试剂。 提供包含一种或多种D型ODN的组合物和调节CXCL16的活性和/或表达的试剂。
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10.发明申请METHOD OF TREATING INFLAMMATORY ARTHROPATHIES WITH SUPPRESSORS OF CPG OLIGONUCLEOTIDES 有权用CPG寡核苷酸抑制剂治疗炎症性脑病的方法公开(公告)号：US20110201676A1
公开(公告)日：2011-08-18
申请号：US13093725
申请日：2011-04-25
IPC分类号： A61K31/7088 , C07H21/04 , A61P19/02 , A61P29/00 , A61P37/06
CPC分类号： C12N15/117 , A61K31/7088 , A61K38/00 , A61K45/06 , C12N2310/18 , C12N2310/315
摘要： The present disclosure relates to oligodeoxynucleotides that suppress an immune response. Methods are disclosed for preventing or treating inflammatory arthropathies by administering a therapeutically effective amount of a suppressive oligodeoxynucleotide.
摘要翻译： 本公开涉及抑制免疫应答的寡脱氧核苷酸。 公开了通过施用治疗有效量的抑制性寡脱氧核苷酸来预防或治疗炎症性关节病的方法。
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