利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

20 条记录 (耗时 0.03 秒)

    METHODS OF ALTERING AN IMMUNE RESPONSE INDUCED BY CPG OLIGODEOXYNUCLEOTIDES
    1.
    发明申请
    METHODS OF ALTERING AN IMMUNE RESPONSE INDUCED BY CPG OLIGODEOXYNUCLEOTIDES 有权
    改变CPG寡糖氧化酶诱导的免疫反应的方法

    公开(公告)号：US20110110883A1

    公开(公告)日：2011-05-12

    申请号：US13005488

    申请日：2011-01-12

    申请人： Dennis M. Klinman ,  Mayda Gursel ,  Ihsan Gursel

    发明人： Dennis M. Klinman ,  Mayda Gursel ,  Ihsan Gursel

    IPC分类号： A61K31/7088 ,  A61K38/19 ,  A61K38/21 ,  A61K39/00 ,  A61P37/04 ,  A61P31/04 ,  A61P31/12 ,  A61P31/10 ,  A61P31/00 ,  A61P35/00

    CPC分类号： C12N15/117 ,  C12N15/111 ,  C12N2310/17 ,  C12N2320/50

    摘要： It is disclosed herein that agents that affect the activity and/or expression of CXCL16 can be used to alter the uptake of D-type CpG oligodeoxynucleotides (D ODNs). Methods of inducing an immune response are disclosed that include administering agents that increase the activity and/or expression of CXCL16 and a D ODN. Methods of decreasing an immune response to a CpG ODN are also disclosed. These methods include administering an agent that decreases the activity and/or expression of CXCL16. Compositions including one or more D-type ODNs and an agent that modulates that activity and/or expression of CXCL16 are provided.

    摘要翻译： 本文公开了影响CXCL16的活性和/或表达的药剂可用于改变D型CpG寡脱氧核苷酸（D ODN）的摄取。 公开了诱导免疫应答的方法，其包括增加CXCL16和DODN的活性和/或表达的施用试剂。 还公开了降低对CpG ODN的免疫应答的方法。 这些方法包括施用降低CXCL16的活性和/或表达的试剂。 提供包含一种或多种D型ODN的组合物和调节CXCL16的活性和/或表达的试剂。

    Washing and chilling apparatus and method
    5.
    发明申请
    Washing and chilling apparatus and method 有权
    使用空间稳定的阳离子脂质体在体内高效地输送CPG寡核苷酸

    公开(公告)号：US20050214355A1

    公开(公告)日：2005-09-29

    申请号：US10484991

    申请日：2002-07-30

    申请人： Dennis Klinman ,  Ihsan Gursel ,  Ken Ishii ,  Koji Kawakami ,  Bharat Joshi ,  Raj Puri

    发明人： Dennis Klinman ,  Ihsan Gursel ,  Ken Ishii ,  Koji Kawakami ,  Bharat Joshi ,  Raj Puri

    IPC分类号： A61K9/127 ,  A61K39/00 ,  A61K39/39

    CPC分类号： A61K9/1272 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  Y02A50/41 ,  Y02A50/412

    摘要： Sterically stabilized cationic liposomes (SSCL) encapsulating a K type oligodeoxynucleotide (ODN) including a CpG motif are disclosed. These SSCL encapuslating a K type ODN can be used to effectively deliver the ODN to a cell. A novel method is also disclosed for producing the SSCL encapsulating the K type ODN. Administration of the SSCL encapsulating a K type ODN and a chemotherapeutic agent, such as a chimeric molecule comprising a targeting molecule selected from the group consisting of an IL-13, and an anti-IL-13 receptor antibody; and an effector molecule selected from the group consisting of a Pseudomonas exotoxin, a Diphtheria toxin, and a radionuclide, can be used to dramatically reduce the growth of solid tumors.

    摘要翻译： 公开了封装包含CpG基序的K型寡脱氧核苷酸（ODN）的稳定的阳离子脂质体（SSCL）。 封装K型ODN的这些SSCL可用于有效地将ODN传递到一个单元。 还公开了一种用于生产封装K型ODN的SSCL的新方法。 施用包封K型ODN的SSCL和化学治疗剂，例如包含选自IL-13和抗IL-13受体抗体的靶向分子的嵌合分子; 和选自假单胞菌外毒素，白喉毒素和放射性核素的效应分子可用于显着降低实体瘤的生长。

    Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo
    9.
    发明授权
    Use of sterically stabilized cationic liposomes to efficiently deliver CPG oligonucleotides in vivo 有权
    使用空间稳定的阳离子脂质体在体内高效地输送CPG寡核苷酸

    公开(公告)号：US07666674B2

    公开(公告)日：2010-02-23

    申请号：US10484991

    申请日：2002-07-29

    申请人： Dennis M. Klinman ,  Ihsan Gursel ,  Ken J. Ishii

    发明人： Dennis M. Klinman ,  Ihsan Gursel ,  Ken J. Ishii

    IPC分类号： C12N5/00 ,  C12N5/02 ,  A61K9/127 ,  A61K31/70 ,  A01N43/04

    CPC分类号： A61K9/1272 ,  A61K39/39 ,  A61K2039/55555 ,  A61K2039/55561 ,  Y02A50/41 ,  Y02A50/412

    摘要： Sterically stabilized cationic liposomes (SSCL) encapsulating a K type oligodeoxynucleotide (ODN) including a CpG motif are disclosed. These SSCL encapuslating a K type ODN can be used to effectively deliver the ODN to a cell. A novel method is also disclosed for producing the SSCL encapsulating the K type ODN. Administration of the SSCL encapsulating a K type ODN and a chemotherapeutic agent, such as a chimeric molecule comprising a targeting molecule selected from the group consisting of an IL-13, and an anti-IL-13 receptor antibody; and an effector molecule selected from the group consisting of a Pseudomonas exotoxin, a Diphtheria toxin, and a radionuclide, can be used to dramatically reduce the growth of solid tumors.

    摘要翻译： 公开了封装包含CpG基序的K型寡脱氧核苷酸（ODN）的稳定的阳离子脂质体（SSCL）。 封装K型ODN的这些SSCL可用于有效地将ODN传递到一个单元。 还公开了一种用于生产封装K型ODN的SSCL的新方法。 施用包封K型ODN的SSCL和化学治疗剂，例如包含选自IL-13和抗IL-13受体抗体的靶向分子的嵌合分子; 和选自假单胞菌外毒素，白喉毒素和放射性核素的效应分子可用于显着降低实体瘤的生长。