发明授权
- 专利标题: Magnetic rotation to improve signal-over-background in biosensing
- 专利标题(中): 磁旋转以改善生物传感中的背景信号
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申请号: US11569084申请日: 2005-05-13
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公开(公告)号: US07892817B2公开(公告)日: 2011-02-22
- 发明人: Menno Willem Jose Prins , Martinus Barnardus Van Der Mark , Paulus Cornelis Duineveld , Mischa Megens , Josephus Arnoldus Henricus Maria Kahlman
- 申请人: Menno Willem Jose Prins , Martinus Barnardus Van Der Mark , Paulus Cornelis Duineveld , Mischa Megens , Josephus Arnoldus Henricus Maria Kahlman
- 申请人地址: NL Eindhoven
- 专利权人: Koninklijke Philips Electronics, N.V.
- 当前专利权人: Koninklijke Philips Electronics, N.V.
- 当前专利权人地址: NL Eindhoven
- 优先权: EP04102175 20040518
- 国际申请: PCT/IB2005/051574 WO 20050513
- 国际公布: WO2005/111596 WO 20051124
- 主分类号: C12M3/00
- IPC分类号: C12M3/00
摘要:
A method and a device are provided for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom while the magnetic nanoparticle is attached to the surface. The method and device may be applied to in-vivo and in-vitro biomolecular diagnostics. The sensor combines in one sensor the detection of magnetic particles or labels and determination of the binding quality and the properties of magnetic particles or labels which are bound to the surface of another entity.