公开(公告)号：US07892817B2

公开(公告)日：2011-02-22

申请号：US11569084

申请日：2005-05-13

申请人： Menno Willem Jose Prins ,  Martinus Barnardus Van Der Mark ,  Paulus Cornelis Duineveld ,  Mischa Megens ,  Josephus Arnoldus Henricus Maria Kahlman

发明人： Menno Willem Jose Prins ,  Martinus Barnardus Van Der Mark ,  Paulus Cornelis Duineveld ,  Mischa Megens ,  Josephus Arnoldus Henricus Maria Kahlman

IPC分类号： C12M3/00

CPC分类号： G01N33/54373 ,  B82Y5/00 ,  B82Y25/00 ,  G01N27/745

摘要： A method and a device are provided for distinguishing a specific binding from a less specific binding between at least one magnetic nanoparticle and a surface of another entity by applying a magnetic field and detecting a physical parameter relating to magnetic nanoparticle rotational or motional freedom while the magnetic nanoparticle is attached to the surface. The method and device may be applied to in-vivo and in-vitro biomolecular diagnostics. The sensor combines in one sensor the detection of magnetic particles or labels and determination of the binding quality and the properties of magnetic particles or labels which are bound to the surface of another entity.

摘要翻译： 提供了一种方法和装置，用于通过施加磁场和检测与磁性纳米颗粒旋转或运动自由相关的物理参数来区分特定结合与至少一个磁性纳米颗粒与另一个实体的表面之间的较小特异性结合，同时磁性 纳米颗粒附着在表面。 该方法和装置可以应用于体内和体外生物分子诊断。 该传感器将一个传感器结合在一起，检测磁性颗粒或标签，并确定结合质量以及结合到另一个实体表面的磁性颗粒或标签的性质。