发明授权
US07893246B2 Sirna capable of inhibiting the expression of an oncogene involved in cervical cancer
有权
Sirna能够抑制参与宫颈癌的癌基因的表达
- 专利标题: Sirna capable of inhibiting the expression of an oncogene involved in cervical cancer
- 专利标题(中): Sirna能够抑制参与宫颈癌的癌基因的表达
-
申请号: US12207298申请日: 2008-09-09
-
公开(公告)号: US07893246B2公开(公告)日: 2011-02-22
- 发明人: Akira Saito , Masahiko Kuroda
- 申请人: Akira Saito , Masahiko Kuroda
- 申请人地址: JP Tokyo JP Tokyo
- 专利权人: NEC Corporation,Masahiko Kuroda
- 当前专利权人: NEC Corporation,Masahiko Kuroda
- 当前专利权人地址: JP Tokyo JP Tokyo
- 代理机构: Sughrue Mion, PLLC
- 优先权: JP2003-011478 20030120
- 主分类号: C07H21/04
- IPC分类号: C07H21/04 ; C12N15/11
摘要:
The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an oncogenic protein encoded thereby, and to provide a full-length polynucleotide encoding a peptide chain of the oncogenic protein derived from the novel oncogene, which can be used for recombinant production of the oncogenic protein, and the peptide chain of the oncogenic protein produced recombinantly therewith. Specifically, the present invention provides a novel oncogene polynucleotide from human involving development of cervical cancer, comprising a nucleotide sequence encoding an amino acid sequence of SEQ. ID. No. 1, particularly a polynucleotide of the nucleotide sequence of SEQ. ID. No. 2.