公开(公告)号：US07358350B2

公开(公告)日：2008-04-15

申请号：US10758562

申请日：2004-01-16

申请人： Akira Saito ,  Masahiko Kuroda

发明人： Akira Saito ,  Masahiko Kuroda

IPC分类号： C07H21/02 ,  C07H21/04

CPC分类号： C07K14/82 ,  C07K16/32 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an oncogenic protein encoded thereby, and to provide a full-length polynucleotide encoding a peptide chain of the oncogenic protein derived from the novel oncogene, which can be used for recombinant production of the oncogenic protein, and the peptide chain of the oncogenic protein produced recombinantly therewith. Specifically, the present invention provides a novel oncogene polynucleotide from human involving development of cervical cancer, comprising a nucleotide sequence encoding an amino acid sequence of SEQ. ID. No.1, particularly a polynucleotide of the nucleotide sequence of SEQ. ID. No.2.

摘要翻译： 本发明鉴定了来自人的新型致癌基因的总核苷酸序列，其直接参与由宫颈上皮细胞的HPV感染诱导的宫颈癌和由此编码的致癌蛋白的氨基酸序列的癌变机制， 提供编码衍生自新癌基因的致癌蛋白的肽链的全长多核苷酸，其可用于重组生成致癌蛋白质，以及重组产生的致癌蛋白质的肽链。 具体地，本发明提供了涉及宫颈癌发展的来自人的新型致癌基因多核苷酸，其包含编码SEQ ID NO：1的氨基酸序列的核苷酸序列。 ID。 1，特别是SEQ ID NO：1的核苷酸序列的多核苷酸。 ID。 2号

公开(公告)号：US07893246B2

公开(公告)日：2011-02-22

申请号：US12207298

申请日：2008-09-09

申请人： Akira Saito ,  Masahiko Kuroda

发明人： Akira Saito ,  Masahiko Kuroda

IPC分类号： C07H21/04 ,  C12N15/11

CPC分类号： C07K14/82 ,  C07K16/32 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an oncogenic protein encoded thereby, and to provide a full-length polynucleotide encoding a peptide chain of the oncogenic protein derived from the novel oncogene, which can be used for recombinant production of the oncogenic protein, and the peptide chain of the oncogenic protein produced recombinantly therewith. Specifically, the present invention provides a novel oncogene polynucleotide from human involving development of cervical cancer, comprising a nucleotide sequence encoding an amino acid sequence of SEQ. ID. No. 1, particularly a polynucleotide of the nucleotide sequence of SEQ. ID. No. 2.

摘要翻译： 本发明鉴定了来自人的新型致癌基因的全部核苷酸序列，其直接涉及由HPV感染宫颈上皮细胞诱导的宫颈癌及其编码的致癌蛋白的氨基酸序列的癌化机制， 提供编码衍生自新癌基因的致癌蛋白的肽链的全长多核苷酸，其可用于重组生成致癌蛋白质，以及重组产生的致癌蛋白质的肽链。 具体地，本发明提供了涉及宫颈癌发展的来自人的新型致癌基因多核苷酸，其包含编码SEQ ID NO：1的氨基酸序列的核苷酸序列。 ID。 特别是SEQ ID NO：1的核苷酸序列的多核苷酸。 ID。 第2号。

公开(公告)号：US20060217342A1

公开(公告)日：2006-09-28

申请号：US11449671

申请日：2006-06-09

申请人： Akira Saito ,  Masahiko Kuroda

发明人： Akira Saito ,  Masahiko Kuroda

IPC分类号： A61K48/00 ,  G01N33/574 ,  C07H21/02 ,  C07K14/82 ,  C07K16/30

CPC分类号： C07K14/82 ,  C07K16/32 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an oncogenic protein encoded thereby, and to provide a full-length polynucleotide encoding a peptide chain of the oncogenic protein derived from the novel oncogene, which can be used for recombinant production of the oncogenic protein, and the peptide chain of the oncogenic protein produded recombinantly therewith. Specifically, the present invention provides a novel oncogene polynucleotide from human involving development of cervical cancer, comprising a nucleotide sequence encoding an amino acid sequence of SEQ. ID. No.1, particularly a polynucleotide of the nucleotide sequence of SEQ. ID. No.2.

摘要翻译： 本发明鉴定了来自人的新型致癌基因的总核苷酸序列，其直接参与由宫颈上皮细胞的HPV感染诱导的宫颈癌和由此编码的致癌蛋白的氨基酸序列的癌变机制， 提供编码衍生自新癌基因的致癌蛋白的肽链的全长多核苷酸，其可用于重组生成致癌蛋白质，以及重组产生的致癌蛋白质的肽链。 具体地，本发明提供了涉及宫颈癌发展的来自人的新型致癌基因多核苷酸，其包含编码SEQ ID NO：1的氨基酸序列的核苷酸序列。 ID。 1，特别是SEQ ID NO：1的核苷酸序列的多核苷酸。 ID。 2号

公开(公告)号：US20120115139A1

公开(公告)日：2012-05-10

申请号：US13265680

申请日：2010-04-21

申请人： Masahiko Kuroda ,  Akira Saito ,  Maki Sano

发明人： Masahiko Kuroda ,  Akira Saito ,  Maki Sano

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Provided is a cancer evaluation method using a novel cancer marker for evaluating the onset, the preclinical stage, the clinical stage, or the prognosis of a cancer in a subject. At least one miRNA selected from hsa-miR-92 and hsa-miR-494 is used as the novel cancer marker in cancer evaluation. The cancer marker in a sample of a cell or a tissue is detected, and the possibility of a cancer in the sample is evaluated based on the expression level of the cancer marker. According to this evaluation method, by detecting the miRNA as the cancer marker, it becomes possible to evaluate the possibility of a cancer in the sample with excellent reliability. As a method for detecting the cancer marker, it is preferable to perform an in situ hybridization method using a labeled probe with respect to the sample that has been immobilized, for example.

摘要翻译： 提供了一种使用新型癌症标志物评价受试者的癌症的发病，临床前期，临床阶段或预后的癌症评价方法。 使用至少一种选自hsa-miR-92和hsa-miR-494的miRNA作为癌症评价中的新型癌症标志物。 检测细胞或组织样品中的癌症标志物，并根据癌症标志物的表达水平评估样品中癌症的可能性。 根据该评价方法，通过检测miRNA作为癌症标记物，可以以极好的可靠性来评价样品中癌症的可能性。 作为检测癌症标记物的方法，优选使用例如相对于被固定化的样品的标记探针进行原位杂交法。

公开(公告)号：US07432358B2

公开(公告)日：2008-10-07

申请号：US11449671

申请日：2006-06-09

申请人： Akira Saito ,  Masahiko Kuroda

发明人： Akira Saito ,  Masahiko Kuroda

IPC分类号： C07K16/00

CPC分类号： C07K14/82 ,  C07K16/32 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/158

摘要： The present invention identifies the total nucleotide sequence of a novel oncogene from human, which is directly involved in such a cancerization mechanism as for cervical cancer induced by HPV infection of cervical epithelial cell and the amino acid sequence of an oncogenic protein encoded thereby, and to provide a full-length polynucleotide encoding a peptide chain of the oncogenic protein derived from the novel oncogene, which can be used for recombinant production of the oncogenic protein, and the peptide chain of the oncogenic protein produced recombinantly therewith. Specifically, the present invention provides a novel oncogene polynucleotide from human involving development of cervical cancer, comprising a nucleotide sequence encoding an amino acid sequence of SEQ. ID. No.1, particularly a polynucleotide of the nucleotide sequence of SEQ. ID. No.2.

公开(公告)号：US10682808B2

公开(公告)日：2020-06-16

申请号：US16056855

申请日：2018-08-07

申请人： Takashi Fujita ,  Akira Saito ,  Kiichi Kamoda ,  Yasutada Shitara ,  Kazuhiko Watanabe ,  Hitoshi Iwatsuki ,  Yuuya Endoh ,  Kazufumi Kimura ,  Yasuyuki Yamashita ,  Shinnosuke Koshizuka ,  Yuuki Kamon ,  Nozomu Tamoto

发明人： Takashi Fujita ,  Akira Saito ,  Kiichi Kamoda ,  Yasutada Shitara ,  Kazuhiko Watanabe ,  Hitoshi Iwatsuki ,  Yuuya Endoh ,  Kazufumi Kimura ,  Yasuyuki Yamashita ,  Shinnosuke Koshizuka ,  Yuuki Kamon ,  Nozomu Tamoto

IPC分类号： B29C64/147 ,  B29C64/218 ,  B29C64/40

摘要： A fabrication method includes laminating a fabrication material to form an object, and applying a release material on a surface of the object to form a release layer on the surface of the object. A surface free energy of the release material is equal to or smaller than 25 mN/m.

公开(公告)号：US20190284351A1

公开(公告)日：2019-09-19

申请号：US16351092

申请日：2019-03-12

申请人： Shigenori YAGUCHI ,  Yasuyuki Yamashita ,  Akira Saito ,  Kiichi Kamoda

发明人： Shigenori YAGUCHI ,  Yasuyuki Yamashita ,  Akira Saito ,  Kiichi Kamoda

IPC分类号： C08J5/04 ,  C08J3/12 ,  B29C70/62

摘要： Provided are resin particles including columnar resin particles each including filaments of a fibrous material, wherein the filaments of the fibrous material are aligned in an axial direction of each of the columnar resin particles.

公开(公告)号：US09173754B2

公开(公告)日：2015-11-03

申请号：US13060395

申请日：2009-08-28

申请人： Yoshihiko Yokoi ,  Yasushi Hashimoto ,  Akira Saito

发明人： Yoshihiko Yokoi ,  Yasushi Hashimoto ,  Akira Saito

IPC分类号： A61F2/82 ,  A61F2/89

CPC分类号： A61F2/89 ,  A61F2250/0018

摘要： A stent including a plurality of loop stents connected by struts so that it bends uniformly as a whole.A stent A including a plurality of loop stents 2 connected by a plurality of struts 3, the loop stents 2 each formed of a stent main wire 1 folded into a zigzag shape and joined at its ends, wherein the bending strength of each strut 3 is larger than the bending strength of the stent main wire 1.

摘要翻译： 一种支架，其包括通过支柱连接的多个环形支架，使得其整体上均匀地弯曲。 支架A，其包括多个由多个支柱3连接的环形支架2，每个支架2由支架主线1形成，折叠成Z字形并在其端部连接，其中每个支柱3的弯曲强度为 大于支架主线1的弯曲强度。

公开(公告)号：US20150076124A1

公开(公告)日：2015-03-19

申请号：US14486919

申请日：2014-09-15

申请人： Kengo Tsubaki ,  Yoshiyuki Araseki ,  Akira Saito

发明人： Kengo Tsubaki ,  Yoshiyuki Araseki ,  Akira Saito

IPC分类号： B23K10/00 ,  B23K9/28

CPC分类号： B41J2/06 ,  B41J11/0015 ,  H05H1/2406 ,  H05H1/46 ,  H05H2001/2412 ,  H05H2001/4682

摘要： A processing target reforming apparatus includes: a conveying unit that conveys a processing target along a conveyance path; a discharge unit including a plurality of discharge electrodes aligned along the conveyance path, a counter electrode with the conveyance path interposed therebetween, and a power source that applies a voltage waveform to the discharge electrodes; and a control unit that controls the discharge unit such that a phase of the voltage waveform applied to a first discharge electrode of the discharge electrodes at a timing when a certain point of the processing target passes between the first discharge electrode and the counter electrode is shifted with respect to a phase of the voltage waveform applied by the power source to a second discharge electrode of the discharge electrodes at a timing when the certain point of the processing target passes between the second discharge electrode and the counter electrode.

摘要翻译： 一种加工对象重整装置，包括：输送单元，其沿着输送路径输送加工对象物; 放电单元，包括沿着输送路径排列的多个放电电极，具有介于其间的输送路径的对置电极和向放电电极施加电压波形的电源; 以及控制单元，其控制所述放电单元，使得在所述处理对象的某一点在所述第一放电电极和所述对置电极之间通过的时刻的施加到所述放电电极的第一放电电极的电压波形的相位偏移 相对于处理对象的特定点在第二放电电极和对电极之间通过的时刻，由电源对放电电极的第二放电电极施加的电压波形的相位。

公开(公告)号：US20150000803A1

公开(公告)日：2015-01-01

申请号：US14366921

申请日：2011-12-22

申请人： Jun-Ichi Kumagai ,  Yoshio Abe ,  Akira Saito ,  Shuzo Umezu ,  Ryo Iino

发明人： Jun-Ichi Kumagai ,  Yoshio Abe ,  Akira Saito ,  Shuzo Umezu ,  Ryo Iino

IPC分类号： C22F1/08 ,  C22C9/04 ,  C22C9/06

CPC分类号： C22F1/08 ,  C22C9/04 ,  C22C9/06 ,  H01B1/026

摘要： A Cu—Ni—Si-based copper alloy sheet of the invention has excellent mold abrasion resistance and shear workability while maintaining strength and conductivity, in which 1.0 mass % to 4.0 mass % of Ni is contained, 0.2 mass % to 0.9 mass % of Si is contained, the remainder is made up of Cu and inevitable impurities. The number of the Ni—Si precipitate particles having a grain diameter in a range of 20 nm to 80 nm in a surface layer that is as thick as 20% of the entire sheet thickness from the surface is represented by a particles/mm2, and the number of the Ni—Si precipitate particles having a grain diameter in a range of 20 nm to 80 nm in a portion below the surface layer is represented by b particles/mm2, a/b is in a range of 0.5 to 1.5.

摘要翻译： 本发明的Cu-Ni-Si系铜合金板在保持强度和导电性的同时具有优异的模具耐磨性和剪切加工性，其中含有1.0质量％至4.0质量％的Ni，0.2质量％至0.9质量％ 含有Si，其余部分由Cu和不可避免的杂质构成。 在表面层厚度为20nm〜80nm范围内的Ni-Si析出物颗粒的数量比表面积为整个板厚的20％以粒子数/ mm2表示， 在表面层下面的部分，粒径在20nm〜80nm范围内的Ni-Si析出物颗粒的数量由b颗粒/ mm 2表示，a / b在0.5〜1.5的范围内。