发明授权
- 专利标题： TRAIL receptor-binding agents and uses of the same
- 专利标题（中）： TRAIL受体结合剂及其用途
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申请号： US12298001申请日： 2007-04-29
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公开(公告)号： US07897730B2公开(公告)日： 2011-03-01
- 发明人: Zheng Yu , Min Zhou , Enyun Shen , Xianzhao Jia , Yang Song
- 申请人： Zheng Yu , Min Zhou , Enyun Shen , Xianzhao Jia , Yang Song
- 申请人地址： CN Beijing
- 专利权人： Beijing Cotimes Biotech Ltd.
- 当前专利权人： Beijing Cotimes Biotech Ltd.
- 当前专利权人地址： CN Beijing
- 代理机构： Foley & Lardner LLP
- 优先权： CN200610079301 20060430; CN200610109138 20070306
- 国际申请： PCT/CN2007/001453 WO 20070429
- 国际公布： WO2007/128321 WO 20071115
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K17/00 ; C07K17/14 ; C12P21/08 ; A61K39/395 ; A61K39/00
摘要：
This invention relates generally to the preparation of TRAIL receptor-binding agents and uses of the same. In particular, the present invention relates to the preparation of anti-TRAIL receptor antibodies which recognize a common antigen determinant (i.e., epitope) shared by TRAIL-R1 and TRAIL-R2 receptors and their use for TRAIL receptor detection and modulation of TRAIL receptor-mediated function. The TRAIL receptor-binding agents are useful to induce apoptosis in human cancer cells. These targets may either express one or both TRAIL-R1 or TRAIL-R2. The invention provides for the use of the TRAIL receptor-binding agents of the invention in cancer therapy.
公开/授权文献
- US20090136503A1 TRAIL RECEPTOR-BINDING AGENTS AND USES OF THE SAME 公开/授权日：2009-05-28
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