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公开(公告)号：US07897730B2
公开(公告)日：2011-03-01
申请号：US12298001
申请日：2007-04-29
申请人： Zheng Yu , Min Zhou , Enyun Shen , Xianzhao Jia , Yang Song
发明人： Zheng Yu , Min Zhou , Enyun Shen , Xianzhao Jia , Yang Song
CPC分类号： C07K16/2878 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/73
摘要： This invention relates generally to the preparation of TRAIL receptor-binding agents and uses of the same. In particular, the present invention relates to the preparation of anti-TRAIL receptor antibodies which recognize a common antigen determinant (i.e., epitope) shared by TRAIL-R1 and TRAIL-R2 receptors and their use for TRAIL receptor detection and modulation of TRAIL receptor-mediated function. The TRAIL receptor-binding agents are useful to induce apoptosis in human cancer cells. These targets may either express one or both TRAIL-R1 or TRAIL-R2. The invention provides for the use of the TRAIL receptor-binding agents of the invention in cancer therapy.
摘要翻译： 本发明一般涉及TRAIL受体结合剂的制备及其应用。 特别地，本发明涉及抗TRAIL受体抗体的制备，其识别由TRAIL-R1和TRAIL-R2受体共有的共同抗原决定簇（即表位）及其用于TRAIL受体检测和调节TRAIL受体 - 介导功能。 TRAIL受体结合剂可用于诱导人类癌细胞凋亡。 这些靶标可以表达一个或两个TRAIL-R1或TRAIL-R2。 本发明提供本发明的TRAIL受体结合剂在癌症治疗中的用途。
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公开(公告)号：US20090136503A1
公开(公告)日：2009-05-28
申请号：US12298001
申请日：2007-04-29
申请人： Zheng Yu , Min Zhou , Enyun Shen , Xianzhao Jia , Yang Song
发明人： Zheng Yu , Min Zhou , Enyun Shen , Xianzhao Jia , Yang Song
CPC分类号： C07K16/2878 , A61K2039/505 , A61K2039/507 , C07K2317/24 , C07K2317/73
摘要： This invention relates generally to the preparation of TRAIL receptor-binding agents and uses of the same. In particular, the present invention relates to the preparation of anti-TRAIL receptor antibodies which recognize a common antigen determinant (i.e., epitope) shared by TRAIL-R1 and TRAIL-R2 receptors and their use for TRAIL receptor detection and modulation of TRAIL receptor-mediated function. The TRAIL receptor-binding agents are useful to induce apoptosis in human cancer cells. These targets may either express one or both TRAIL-R1 or TRAIL-R2. The invention provides for the use of the TRAIL receptor-binding agents of the invention in cancer therapy.
摘要翻译： 本发明一般涉及TRAIL受体结合剂的制备及其用途。 特别地，本发明涉及抗TRAIL受体抗体的制备，其识别由TRAIL-R1和TRAIL-R2受体共有的共同抗原决定簇（即表位）及其用于TRAIL受体检测和调节TRAIL受体 - 介导功能。 TRAIL受体结合剂可用于诱导人类癌细胞凋亡。 这些靶标可以表达一个或两个TRAIL-R1或TRAIL-R2。 本发明提供本发明的TRAIL受体结合剂在癌症治疗中的用途。
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公开(公告)号：US20110207152A1
公开(公告)日：2011-08-25
申请号：US12673134
申请日：2007-08-15
申请人： Enyun Shen , Zheng Yu , Min Zhou , Fei Guo
发明人： Enyun Shen , Zheng Yu , Min Zhou , Fei Guo
CPC分类号： C07K16/18 , C07K2317/565 , C07K2317/73 , G01N2800/26 , G01N2800/52 , G01N2800/56
摘要： The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination, to detect a gelsolin polypeptide (a.k.a., the target polypeptide) in a test sample as well as to purify native gelsolin proteins. Gelsolin binding agents are also useful to diagnose, a gelsolin related medical condition in subjects in need thereof. Kits to detect gelsolin in biological samples are provided by the present invention.
摘要翻译： 本发明一般涉及可结合凝溶胶蛋白多肽的凝溶胶蛋白结合剂（例如，抗体）。 本发明的凝溶胶蛋白结合剂单独或组合用于检测测试样品中的凝溶胶蛋白多肽（即即，目标多肽）以及纯化天然凝溶胶蛋白。 凝溶胶蛋白结合剂也可用于诊断有需要的受试者中的凝溶胶蛋白相关的医学状况。 用于检测生物样品中凝溶胶蛋白的试剂盒由本发明提供。
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公开(公告)号：US08367356B2
公开(公告)日：2013-02-05
申请号：US12673134
申请日：2007-08-15
申请人： Enyun Shen , Zheng Yu , Min Zhou , Fei Guo
发明人： Enyun Shen , Zheng Yu , Min Zhou , Fei Guo
IPC分类号： C07K16/18 , C07K16/40 , C12N5/20 , G01N33/53 , G01N33/543 , G01N33/563 , G01N33/573 , G01N33/577
CPC分类号： C07K16/18 , C07K2317/565 , C07K2317/73 , G01N2800/26 , G01N2800/52 , G01N2800/56
摘要： The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination, to detect a gelsolin polypeptide (a.k.a., the target polypeptide) in a test sample as well as to purify native gelsolin proteins. Gelsolin binding agents are also useful to diagnose, a gelsolin related medical condition in subjects in need thereof. Kits to detect gelsolin in biological samples are provided by the present invention.
摘要翻译： 本发明一般涉及可结合凝溶胶蛋白多肽的凝溶胶蛋白结合剂（例如，抗体）。 本发明的凝溶胶蛋白结合剂单独或组合用于检测测试样品中的凝溶胶蛋白多肽（即即，目标多肽）以及纯化天然凝溶胶蛋白。 凝溶胶蛋白结合剂也可用于诊断有需要的受试者中的凝溶胶蛋白相关的医学状况。 用于检测生物样品中凝溶胶蛋白的试剂盒由本发明提供。
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公开(公告)号：US20120156700A1
公开(公告)日：2012-06-21
申请号：US12673139
申请日：2008-08-15
申请人： Enyun Shen , Zheng Yu , Min Zhou , Fei Guo
发明人： Enyun Shen , Zheng Yu , Min Zhou , Fei Guo
IPC分类号： G01N33/566 , C07K16/00
CPC分类号： C07K16/18 , C07K2317/565 , C07K2317/73 , G01N2800/26 , G01N2800/52 , G01N2800/56
摘要： The invention relates generally to gelsolin binding agents (e.g., antibodies) which can bind to gelsolin polypeptides. Gelsolin binding agents of the invention are useful, alone or in combination, to detect a gelsolin polypeptide in a test sample. In particular, the gelsolin binding agents are useful in assays of urine samples to diagnose a gelsolin-related medical condition. Kits to detect gelsolin in biological samples are also provided by the present disclosure.
摘要翻译： 本发明一般涉及可结合凝溶胶蛋白多肽的凝溶胶蛋白结合剂（例如，抗体）。 本发明的凝溶胶蛋白结合剂单独或组合用于检测测试样品中的凝溶胶蛋白多肽。 特别地，凝溶胶蛋白结合剂可用于尿液样品的测定以诊断凝溶胶蛋白相关的医学状况。 本发明还提供用于检测生物样品中凝溶胶蛋白的试剂盒。
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6.发明授权Method and device for determining search space, and method and device for determining candidate control channel resources 有权用于确定搜索空间的方法和装置，以及用于确定候选控制信道资源的方法和装置公开(公告)号：US08553713B2
公开(公告)日：2013-10-08
申请号：US13406302
申请日：2012-02-27
申请人： Chaojun Li , Lixia Xue , Bingyu Qu , Lei Guan , Zheng Yu
发明人： Chaojun Li , Lixia Xue , Bingyu Qu , Lei Guan , Zheng Yu
CPC分类号： H04W48/16 , H04L1/0027 , H04L1/003 , H04L5/001 , H04L5/0042 , H04L5/0053 , H04W48/12 , H04W72/042
摘要： A method and a device for determining a search space and for determining candidate control channel resources are provided in present invention. The method for determining the search space includes: determining the number of downlink control information bits of each type of control channel currently required to be monitored by a UE; determining a temporary search space corresponding to the each type of control channel according to a mapping relationship currently used by the UE; and determining that an actual search space corresponding to a selected type of control channel is all or a part of CCEs of a union of temporary search spaces corresponding to all or a part of control channels with the same number of the downlink control information bits, when the DCI bit number of one or more other control channels is the same as the DCI bit number of the selected type of control channel.
摘要翻译： 本发明提供了一种确定搜索空间和确定候选控制信道资源的方法和装置。 用于确定搜索空间的方法包括：确定当前需要由UE监视的每种类型的控制信道的下行控制信息比特数; 根据UE当前使用的映射关系，确定与每种类型的控制信道相对应的临时搜索空间; 并且确定与所选类型的控制信道相对应的实际搜索空间是与具有相同数量的下行链路控制信息比特的全部或一部分控制信道对应的临时搜索空间的联合的CCE的全部或一部分，当 一个或多个其他控制信道的DCI比特数与所选类型的控制信道的DCI比特数相同。
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公开(公告)号：US20120327886A1
公开(公告)日：2012-12-27
申请号：US13593958
申请日：2012-08-24
申请人： Zheng Yu , Lixia Xue , Xiao'an Fan , Chaojun Li
发明人： Zheng Yu , Lixia Xue , Xiao'an Fan , Chaojun Li
CPC分类号： H04W72/04 , H04L5/0051 , H04L27/2613 , H04W72/042 , H04W72/1268
摘要： The present invention discloses a data transmission method, a base station, and a communication system, which are applied in the communication field. The method includes: determining to perform semi-persistent scheduling on data of a user equipment; setting a value of first information for the user equipment, so that the user equipment determines a cyclic shift value of a reference signal sequence of the user equipment according to the value of the first information; and obtaining the reference signal sequence of the user equipment, performing channel estimation according to the reference signal sequence of the user equipment, and performing demodulation on data information of the user equipment according to a channel coefficient obtained by performing the channel estimation.
摘要翻译： 本发明公开了一种应用于通信领域的数据传输方法，基站和通信系统。 该方法包括：确定对用户设备的数据执行半持续调度; 设置用户设备的第一信息的值，使得用户设备根据第一信息的值确定用户设备的参考信号序列的循环移位值; 并获取用户设备的参考信号序列，根据用户设备的参考信号序列进行信道估计，并根据通过进行信道估计得到的信道系数对用户设备的数据信息进行解调。
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公开(公告)号：US08899503B2
公开(公告)日：2014-12-02
申请号：US13322380
申请日：2010-05-25
申请人： Xinguo Yu , Qicheng Le , Zheng Yu
发明人： Xinguo Yu , Qicheng Le , Zheng Yu
IPC分类号： B02C13/28 , B02C13/284 , B02C13/06 , B02C13/04
CPC分类号： B02C13/06 , B02C13/04 , B02C13/284
摘要： A scissor type hammer mill, mainly includes an inlet (1), hammers (2), a rotor (3), a screen (9) and a screen carriage (13) thereof, an outlet (7), a hammermill body (8), and a motor (6), and further includes a stationary hammer frame (4) and stationary hammer blades (5) provided on the stationary hammer frame (4). The stationary hammer frame is fixed on the hammermill body, and the stationary hammer blades are fixed on the stationary hammer frame, the stationary hammer blades are mounted in parallel to a rotation plane of the hammers with a distance therebetween. When the material enters into the cavity of the hammer mill, the material form a rotating material ring after being hit by the hammers, and the material is milled once again after the material ring hits the stationary hammer blade. Meanwhile, the stationary hammer blades lower the rotation speed of the material ring and change the moving direction of the material, and a component force for the movement of material towards a normal direction of the screen apertures is increased, which facilitates improving the milling efficiency, and improve the uniformity of the material to be milled.
摘要翻译： 剪刀式锤磨机主要包括入口（1），锤（2），转子（3），筛网（9）和筛网托架（13），出口（7），锤磨机体（8） ）和电动机（6），并且还包括固定锤架（4）和设置在固定锤架（4）上的固定锤片（5）。 固定锤架固定在锤锤体上，固定锤片固定在固定锤架上，固定锤片与锤体的旋转平面平行安装，间距一定。 当材料进入锤磨机的腔体中时，材料在被锤击之后形成旋转材料环，并且在材料环撞击固定锤片之后再次研磨材料。 同时，固定锤片降低材料环的旋转速度并改变材料的移动方向，并且增加材料向丝网孔的法线方向运动的分力，这有利于提高研磨效率， 并提高待研磨材料的均匀性。
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9.发明申请Method and Device for Determining Search Space, and Method and Device for Determining Candidate Control Channel Resources 有权用于确定搜索空间的方法和装置，以及用于确定候选控制信道资源的方法和装置公开(公告)号：US20120155316A1
公开(公告)日：2012-06-21
申请号：US13406302
申请日：2012-02-27
申请人： Chaojun Li , Lixia Xue , Bingyu Qu , Lei Guan , Zheng Yu
发明人： Chaojun Li , Lixia Xue , Bingyu Qu , Lei Guan , Zheng Yu
CPC分类号： H04W48/16 , H04L1/0027 , H04L1/003 , H04L5/001 , H04L5/0042 , H04L5/0053 , H04W48/12 , H04W72/042
摘要： A method and a device for determining a search space and for determining candidate control channel resources are provided in present invention. The method for determining the search space includes: determining the number of downlink control information bits of each type of control channel currently required to be monitored by a UE; determining a temporary search space corresponding to the each type of control channel according to a mapping relationship currently used by the UE; and determining that an actual search space corresponding to a selected type of control channel is all or a part of CCEs of a union of temporary search spaces corresponding to all or a part of control channels with the same number of the downlink control information bits, when the DCI bit number of one or more other control channels is the same as the DCI bit number of the selected type of control channel.
摘要翻译： 本发明提供了一种确定搜索空间和确定候选控制信道资源的方法和装置。 用于确定搜索空间的方法包括：确定当前需要由UE监视的每种类型的控制信道的下行控制信息比特数; 根据UE当前使用的映射关系，确定与每种类型的控制信道相对应的临时搜索空间; 并且确定与所选类型的控制信道相对应的实际搜索空间是与具有相同数量的下行链路控制信息比特的全部或一部分控制信道对应的临时搜索空间的联合的CCE的全部或一部分，当 一个或多个其他控制信道的DCI比特数与所选类型的控制信道的DCI比特数相同。
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公开(公告)号：US20120067988A1
公开(公告)日：2012-03-22
申请号：US13322380
申请日：2010-05-25
申请人： Xinguo Yu , Qicheng Le , Zheng Yu
发明人： Xinguo Yu , Qicheng Le , Zheng Yu
IPC分类号： B02C13/286 , B02C13/28
CPC分类号： B02C13/06 , B02C13/04 , B02C13/284
摘要： A scissor type hammer mill, mainly includes an inlet (1), hammers (2), a rotor (3), a screen (9) and a screen carriage (13) thereof, an outlet (7), a hammermill body (8), and a motor (6), and further includes a stationary hammer frame (4) and stationary hammer blades (5) provided on the stationary hammer frame (4). The stationary hammer frame is fixed on the hammermill body, and the stationary hammer blades are fixed on the stationary hammer frame, the stationary hammer blades are mounted in parallel to a rotation plane of the hammers with a distance therebetween. When the material enters into the cavity of the hammer mill, the material form a rotating material ring after being hit by the hammers, and the material is milled once again after the material ring hits the stationary hammer blade. Meanwhile, the stationary hammer blades lower the rotation speed of the material ring and change the moving direction of the material, and a component force for the movement of material towards a normal direction of the screen apertures is increased, which facilitates improving the milling efficiency, and improve the uniformity of the material to be milled.
摘要翻译： 剪刀式锤磨机主要包括入口（1），锤（2），转子（3），筛网（9）和筛网托架（13），出口（7），锤磨机体（8） ）和电动机（6），并且还包括固定锤架（4）和设置在固定锤架（4）上的固定锤片（5）。 固定锤架固定在锤锤体上，固定锤片固定在固定锤架上，固定锤片与锤体的旋转平面平行安装，间距一定。 当材料进入锤磨机的腔体中时，材料在被锤击之后形成旋转材料环，并且在材料环撞击固定锤片之后再次研磨材料。 同时，固定锤片降低材料环的旋转速度并改变材料的移动方向，并且增加材料向丝网孔的法线方向运动的分力，这有利于提高研磨效率， 并提高待研磨材料的均匀性。
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