发明授权
- 专利标题： Methods of determining the level of human tumor necrosis factor receptor-like 2
- 专利标题（中）： 确定人肿瘤坏死因子受体样水平的方法2
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申请号： US12235837申请日： 2008-09-23
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公开(公告)号： US07910321B2公开(公告)日： 2011-03-22
- 发明人: Jian Ni , Craig A. Rosen , Reiner L. Gentz , Sally Doreen P. Lyn , Mark Hurle
- 申请人： Jian Ni , Craig A. Rosen , Reiner L. Gentz , Sally Doreen P. Lyn , Mark Hurle
- 申请人地址： US MD Rockville US PA Philadelphia
- 专利权人： Human Genome Sciences, Inc.,SmithKline Beecham Corporation
- 当前专利权人： Human Genome Sciences, Inc.,SmithKline Beecham Corporation
- 当前专利权人地址： US MD Rockville US PA Philadelphia
- 主分类号： G01N33/48
- IPC分类号： G01N33/48 ; G01N33/53 ; G01N33/563 ; G01N33/577
摘要：
The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
公开/授权文献
- US20090131319A1 Human Tumor Necrosis Factor Receptor-Like 2 公开/授权日：2009-05-21
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