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1.发明授权Methods of determining the level of human tumor necrosis factor receptor-like 2 失效确定人肿瘤坏死因子受体样水平的方法2公开(公告)号：US07910321B2
公开(公告)日：2011-03-22
申请号：US12235837
申请日：2008-09-23
申请人： Jian Ni , Craig A. Rosen , Reiner L. Gentz , Sally Doreen P. Lyn , Mark Hurle
发明人： Jian Ni , Craig A. Rosen , Reiner L. Gentz , Sally Doreen P. Lyn , Mark Hurle
IPC分类号： G01N33/48 , G01N33/53 , G01N33/563 , G01N33/577
CPC分类号： C07K14/7151
摘要： The present invention relates to novel members of the Tumor Necrosis Factor family of receptors. The invention provides isolated nucleic acid molecules encoding a human TR2 receptor and two splice variants thereof. TR2 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of TR2 receptor activity. Also provided are diagnostic methods for detecting disease states related to the aberrant expression of TR2 receptors. Further provided are therapeutic methods for treating disease states related to aberrant proliferation and differentiation of cells which express the TR2 receptors.
摘要翻译： 本发明涉及肿瘤坏死因子家族受体的新成员。 本发明提供编码人TR2受体的分离的核酸分子及其两个剪接变体。 还提供TR2多肽，载体，宿主细胞和用于制备它们的重组方法。 本发明还涉及用于鉴定TR2受体活性的激动剂和拮抗剂的筛选方法。 还提供了用于检测与TR2受体的异常表达相关的疾病状态的诊断方法。 还提供了治疗与表达TR2受体的细胞的异常增殖和分化相关的疾病状态的治疗方法。
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公开(公告)号：US5912161A
公开(公告)日：1999-06-15
申请号：US749337
申请日：1996-11-14
IPC分类号： C12N15/09 , C12N1/21 , C12N9/04 , C12N15/53 , C12N15/74 , C12P7/60 , C12R1/01 , C12R1/02 , C12R1/18 , C07H21/04
CPC分类号： C12N9/0006 , C12N15/74 , C12P7/60
摘要： Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
摘要翻译： 通过定点诱变制备2,5-二酮-D-葡糖酸还原酶A的突变体，A是用于产生2-酮-L-古洛糖酸的酶，抗坏血酸（维生素C）的前体。 这些突变体具有增加的催化活性，增加的表达水平和/或增强的温度稳定性。
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公开(公告)号：US5376544A
公开(公告)日：1994-12-27
申请号：US941414
申请日：1992-09-08
IPC分类号： C12N15/09 , C12N1/21 , C12N9/04 , C12N15/53 , C12N15/74 , C12P7/60 , C12R1/01 , C12R1/02 , C12R1/18
CPC分类号： C12N9/0006 , C12N15/74 , C12P7/60
摘要： Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
摘要翻译： 通过定点诱变制备2,5-二酮-D-葡糖酸还原酶A的突变体，A是用于产生2-酮-L-古洛糖酸的酶，抗坏血酸（维生素C）的前体。 这些突变体具有增加的催化活性，增加的表达水平和/或增强的温度稳定性。
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公开(公告)号：US07256027B1
公开(公告)日：2007-08-14
申请号：US09332886
申请日：1999-06-15
CPC分类号： C12P7/60 , C12N9/0006
摘要： Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
摘要翻译： 通过定点诱变制备2,5-二酮-D-葡糖酸还原酶A的突变体，A是用于产生2-酮-L-古洛糖酸的酶，抗坏血酸（维生素C）的前体。 这些突变体具有增加的催化活性，增加的表达水平和/或增强的温度稳定性。
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公开(公告)号：US20070168135A1
公开(公告)日：2007-07-19
申请号：US10562096
申请日：2004-06-22
申请人： Pankaj Agarwal , William Reisdorf Jr , Sujoy Ghosh , Vinod Kumar , Mark Hurle , Karen Kabnick , Paul McAllister , David Searls , Kay Tatsuoka , Liwen Liu , Michal Magid-Slav , Dmitri Zaykin
发明人： Pankaj Agarwal , William Reisdorf Jr , Sujoy Ghosh , Vinod Kumar , Mark Hurle , Karen Kabnick , Paul McAllister , David Searls , Kay Tatsuoka , Liwen Liu , Michal Magid-Slav , Dmitri Zaykin
IPC分类号： G06F19/00
摘要： A method of identifying a relationship between a set of one or more candidate biomolecules and a set of one or more reference biomolecules, the method including inputting to a computer a query set describing the one or more candidate biomolecules; comparing the query set with a target database describing the one or more reference biomolecules wherein the one or more reference biomolecules grouped into one or more buckets and wherein the one or more reference biomolecules of each bucket share a common property; counting a number of matches between each query set and each buckets of the target database; and statistically analyzing the number of matches to each bucket wherein the presence of a statistically significant match identifies a relationship between a the query set and a bucket of the target database.
摘要翻译： 一种识别一组一个或多个候选生物分子与一组或多个参考生物分子之间的关系的方法，所述方法包括向计算机输入描述所述一个或多个候选生物分子的查询集; 将所述查询集与描述所述一个或多个参考生物分子的目标数据库进行比较，其中所述一个或多个参考生物分子分组成一个或多个桶，并且其中每个桶的一个或多个参考生物分子共享共同性质; 计算每个查询集与目标数据库的每个桶之间的匹配数; 并且统计分析与每个桶的匹配数量，其中存在统计学显着的匹配标识了所述查询集和所述目标数据库的桶之间的关系。
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公开(公告)号：US5583025A
公开(公告)日：1996-12-10
申请号：US249377
申请日：1994-05-24
IPC分类号： C12N15/09 , C12N1/21 , C12N9/04 , C12N15/53 , C12N15/74 , C12P7/60 , C12R1/01 , C12R1/02 , C12R1/18
CPC分类号： C12N9/0006 , C12N15/74 , C12P7/60
摘要： Mutants of 2,5-diketo-D-gluconic acid reductase A, an enzyme used to produce 2-keto-L-gulonic acid, a precursor of ascorbic acid (vitamin C) are prepared by site-directed mutagenesis. These mutants have increased catalytic activity, increased expression levels, and/or enhanced temperature stability.
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