发明授权
US07932351B2 Activin receptor-like kinase-1 proteins having serine-threonine kinase domains
失效
具有丝氨酸 - 苏氨酸激酶结构域的激活素受体样激酶-1蛋白
- 专利标题： Activin receptor-like kinase-1 proteins having serine-threonine kinase domains
- 专利标题（中）： 具有丝氨酸 - 苏氨酸激酶结构域的激活素受体样激酶-1蛋白
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申请号： US11656720申请日： 2007-01-23
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公开(公告)号： US07932351B2公开(公告)日： 2011-04-26
- 发明人: Kohei Miyazono , Peter ten Dijke , Petra Franzen , Hidetoshi Yamashita , Carl-Henrik Heldin
- 申请人： Kohei Miyazono , Peter ten Dijke , Petra Franzen , Hidetoshi Yamashita , Carl-Henrik Heldin
- 申请人地址： US NY New York
- 专利权人： Ludwig Institute for Cancer Research
- 当前专利权人： Ludwig Institute for Cancer Research
- 当前专利权人地址： US NY New York
- 代理机构： Abelman, Frayne & Schwab
- 优先权： GB9224057.1 19921117; GB9304677.9 19930308; GB9304680.3 19930308; GB9311047.6 19930528; GB9313763.6 19930702; GB9136099.2 19930803; GB9321344.5 19931015
- 主分类号： C07K14/71
- IPC分类号： C07K14/71 ; A61K39/00 ; C12P21/02 ; C07H21/04 ; C12N5/00 ; C12N15/09 ; C12N15/12
摘要：
A new receptor family has been identified, of activin-like kinases. Novel proteins have activin/TGF-beta-type I receptor functionality, and have consequential diagnostic/therapeutic utility. They may have a serine/threonine kinase domain, a DFKSRN or DLKSKN sequence in subdomain VIB and/or a GTKRYM sequence in subdomain VIII.
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