发明授权
- 专利标题: Method for producing multiple emulsions that are stable in storage
- 专利标题(中): 用于生产储存稳定的多重乳液的方法
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申请号: US10578329申请日: 2004-10-29
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公开(公告)号: US07943154B2公开(公告)日: 2011-05-17
- 发明人: Olaf Stange , Martina Mutter , Tanja Oswald , Mark Schmitz
- 申请人: Olaf Stange , Martina Mutter , Tanja Oswald , Mark Schmitz
- 申请人地址: DE Leverkusen
- 专利权人: Bayer Technology Services GmnH
- 当前专利权人: Bayer Technology Services GmnH
- 当前专利权人地址: DE Leverkusen
- 代理机构: Baker Donelson Bearman Caldwell & Berkowitz
- 优先权: DE10351644 20031105
- 国际申请: PCT/EP2004/012275 WO 20041029
- 国际公布: WO2005/046635 WO 20050526
- 主分类号: A61K9/113
- IPC分类号: A61K9/113 ; A61K39/00 ; C09K3/00
摘要:
A process is described for the preparation of storage-stable, multiple emulsions of the water/oil/water (W/O/W) type which comprise one or more active ingredients.The process comprises the steps a) stirring the active ingredient into an aqueous phase, b) emulsifying the aqueous phase by passing the aqueous phase through a large-pored, porous membrane into an oil phase, c) phase inversion of the emulsion from b), by cooling the mixture at a cooling rate of at least 0.3 K/min, where an emulsifier is added either to the aqueous phase in a) or to the oil phase in b) or to both phases.
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