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公开(公告)号：US20240285550A1
公开(公告)日：2024-08-29
申请号：US18643595
申请日：2024-04-23
发明人： Sujatha D. SONTI , Joey Roger THOMAS , Jon LENN , Leandro SANTOS , Justin WHITEMAN , Michael DOHERTY , Mary BEDARD , Piyush JAIN
IPC分类号： A61K31/05 , A61K9/00 , A61K9/06 , A61K9/107 , A61K9/113 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/26
CPC分类号： A61K31/05 , A61K9/0014 , A61K9/06 , A61K9/107 , A61K9/113 , A61K47/06 , A61K47/10 , A61K47/14 , A61K47/26
摘要： The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.
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公开(公告)号：US20240277617A1
公开(公告)日：2024-08-22
申请号：US18565886
申请日：2022-04-01
申请人： ECOPOL TECH SL
CPC分类号： A61K9/1277 , A61K8/14 , A61K9/113 , A61K2800/10 , A61K2800/21 , A61K2800/413 , A61K2800/95
摘要： It relates to a multi-walled water-in-oil-in-water nanoencapsulate and to a hybrid water-in-oil-in-water polyurethane/polyurea liposome comprising internal water droplets which are dispersed within larger oil droplets which are themselves dispersed in an external aqueous continuous phase or which form part of structures resembling liposomes; the polymeric walls are obtainable in a water-in-oil and in an oil-in-water emulsification process by phase inversion, respectively. It also relates to its preparation process, and compositions comprising them.
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公开(公告)号：US12029817B2
公开(公告)日：2024-07-09
申请号：US17222022
申请日：2021-04-05
发明人： Chia-Chen Hsu , Nai-Yi Wang , Yu-Chen Cheng , Jinn-Tsyy Lai
IPC分类号： A61K9/113 , A61K9/16 , A61K35/745 , A61K35/747 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61P1/14
CPC分类号： A61K9/113 , A61K9/16 , A61K35/745 , A61K35/747 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/44 , A61P1/14
摘要： The present invention provides a method for manufacturing a water-in-oil-in-water multiple emulsion, comprising: (a) mixing an active component with an internal aqueous phase to form a homogenized mixture; (b) mixing the homogenized mixture with an oleaginous phase to form a water-in-oil emulsion; and (c) mixing the water-in-oil emulsion with an external aqueous phase to form the water-in-oil-in-water multiple emulsion, wherein the external aqueous phase comprises water and an excipient, and wherein the excipient comprises a whey protein concentrate and a modified starch.
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公开(公告)号：US20240156765A1
公开(公告)日：2024-05-16
申请号：US18420262
申请日：2024-01-23
发明人： Monica M. JABLONSKI
IPC分类号： A61K31/197 , A61K9/00 , A61K9/113 , A61P27/06
CPC分类号： A61K31/197 , A61K9/0048 , A61K9/113 , A61P27/06
摘要： This invention is directed to a method of preventing ocular neurodegeneration in a subject in need thereof.
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公开(公告)号：US11968993B2
公开(公告)日：2024-04-30
申请号：US16766502
申请日：2018-11-15
IPC分类号： A23D7/01 , A23D7/015 , A61K8/06 , A61K8/55 , A61K8/60 , A61K8/92 , A61K9/113 , A61K47/24 , A61K47/26 , A61K47/44
CPC分类号： A23D7/011 , A23D7/015 , A61K8/066 , A61K8/553 , A61K8/60 , A61K8/922 , A61K8/925 , A61K9/113 , A61K47/24 , A61K47/26 , A61K47/44
摘要： A water-in-oil-in-water (W1/O/W2) emulsion comprising a lipid phase (O) and a water phase (W2), the lipid phase being distributed inside the water phase, wherein the lipid phase contains water droplets (W1), wherein the water content inside the lipid phase is between 10 wt % and 80 wt % relative to total weight of the lipid phase, wherein the water droplets are stabilized inside the lipid phase by an emulsifier composition, wherein the emulsifier composition comprises an Acetone-insoluble (AI) component containing a Phosphatidyl Choline (PC), a Phosphatidyl Inositol (PI), a Phosphatidyl Ethanolamine (PE) and a Phosphatidic Acid (PA), wherein PC is at most 15.5% relative to the total weight of the emulsifier composition and wherein the emulsifier composition has a phospholipid weight ratio R of at most 65%, the ratio R being defined according to Formula R(in %)=100×(PC+PI+PE+PA)/AI.
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6.发明公开公开(公告)号：US20230181658A1
公开(公告)日：2023-06-15
申请号：US17994162
申请日：2023-02-13
发明人： Yijie Chen , Jinyu Chen , Qi Zhou , Beixi Li , Qian Shen , Wei Zheng , Yilun Luo , Shuang Ding , Fei Han , Liuqing Yang
IPC分类号： A61K35/747 , A61K9/113 , A61K47/24 , A61K9/00 , A61K47/34
CPC分类号： A61K35/747 , A61K9/0095 , A61K9/113 , A61K47/24 , A61K47/34
摘要： A method for preparing a probiotic preparation based on a W1/O/W2 double emulsion structure includes steps of: using a solution containing probiotics or a mixed solution of probiotics and a probiotic protective agent as an internal water phase W1; dissolving an emulsifier in a lipid phase O, and mixing the lipid phase O with the internal water phase W1; then preparing a primary emulsion W1/O by stirring and low-energy emulsification or high-energy emulsification; and using an emulsifier-contained solution as an external water phase W2, and adding the external water phase W2 to the primary emulsion W1/O; then preparing a W1/O/W2 double emulsion by stirring and the low-energy emulsification or the high-energy emulsification, thereby obtaining the probiotic preparation. The double emulsion system is used to embed the probiotics, which can keep the probiotics active during low-temperature storage and freezing and thawing.
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公开(公告)号：US11648316B2
公开(公告)日：2023-05-16
申请号：US16763844
申请日：2018-10-10
申请人： ICURE BNP CO., LTD.
发明人： Jin Woo Park , Young Ro Byun , Young Kweon Choi , Kwan Young Chang , Jae Bum Lee
IPC分类号： A61K47/54 , A61K9/00 , A61K31/519 , A61K47/10 , A61K9/113 , A61K9/20 , A61K9/48 , A61K31/353 , A61K31/513 , A61K31/575 , A61K47/26 , A61K47/40 , A61K47/44
CPC分类号： A61K47/554 , A61K9/0053 , A61K9/113 , A61K9/2095 , A61K9/4833 , A61K31/353 , A61K31/513 , A61K31/519 , A61K31/575 , A61K47/10 , A61K47/26 , A61K47/40 , A61K47/44
摘要： The present invention relates to an oral pharmaceutical composition containing pemetrexed as a water-soluble anticancer drug and a method of manufacturing the same, and more particularly to an oral pharmaceutical composition, in which an ion-binding complex of pemetrexed and a bile acid derivative as an oral absorption enhancer is formed, mixed with a pharmaceutical additive, and then provided in the form of a capsule or a tablet through pressing or included in the internal water phase of a w/o/w (water-in-oil-in-water) multiple nanoemulsion, thus increasing the oral bioavailability of pemetrexed as the water-soluble anticancer drug, whereby pemetrexed, which is currently administered only in the form of an injection formulation, can be manufactured into a formulation capable of being orally administered, ultimately alleviating inconvenience and problems with use of injection formulations, improving patient compliance and contributing to a reduction in medical expenses.
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公开(公告)号：US11612573B2
公开(公告)日：2023-03-28
申请号：US16587833
申请日：2019-09-30
发明人： Sujatha D. Sonti , Joey Roger Thomas , Jon Lenn , Leandro Santos , Justin Whiteman , Michael Doherty , Mary Bedard , Piyush Jain
IPC分类号： A61K9/00 , A61K9/107 , A61K47/06 , A61K47/44 , A61K31/05 , A61K9/113 , A61K9/06 , A61K47/08 , A61K47/10 , A61K47/22
摘要： The present invention relates to topical pharmaceutical emulsion compositions comprising a therapeutically effective amount of 3,5-Dihydroxy-4-isopropyl-trans-stilbene or a pharmaceutically acceptable salt thereof, an oil phase, a water phase, a surfactant, and an antioxidant, and wherein the emulsion composition is homogeneous and/or the active is solubilized in the oil phase. The invention also relates to methods of treating a dermatological condition or disorder in a patient by administering the present compositions to the skin of the patient.
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公开(公告)号：US11596780B2
公开(公告)日：2023-03-07
申请号：US14893115
申请日：2014-05-28
发明人： Colin Cook , Warren Grayson
IPC分类号： A61M37/00 , A61M16/12 , A61L27/56 , A61L27/52 , A61L27/38 , A61L27/54 , A61K9/113 , C12N5/077
摘要： Devices and methods for delivering oxygen and other therapeutic gases to a target, such as a tissue, a tissue-engineered construct, and a wound, in a controlled and sustained manner are disclosed.
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公开(公告)号：US20210353758A1
公开(公告)日：2021-11-18
申请号：US17286925
申请日：2020-01-29
发明人： Jongoh PARK , Eunpyo CHOI , Chang-Sei KIM , Gwangjun GO , Jiwon HAN
IPC分类号： A61K47/34 , A61K9/16 , A61K31/704 , A61K31/7068 , A61K33/243 , A61K31/282 , A61K31/675 , A61K31/7048 , A61K31/138 , A61K38/14 , A61K31/475 , A61K47/32 , A61K9/113
摘要： The present disclosure relates to a microcarrier for embolization, and a preparation method therefor, wherein the microcarrier comprises a biodegradable porous polymer, a stimulus-responsive polymer captured in the biodegradable porous polymer, and drug-supported magnetic nanoparticles captured in the stimulus-responsive polymer, thereby being capable of operating in an in vivo tumor-targeting manner and releasing, by an external stimulus, the drug-supported nanoparticles, so as to be effectively usable in tumor embolization.
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