发明授权
US07977371B2 Pyrrole derivative having ureido group and aminocarbonyl group as substituents
失效
具有脲基和氨基羰基的吡咯衍生物作为取代基
- 专利标题: Pyrrole derivative having ureido group and aminocarbonyl group as substituents
- 专利标题(中): 具有脲基和氨基羰基的吡咯衍生物作为取代基
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申请号: US12449794申请日: 2008-02-26
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公开(公告)号: US07977371B2公开(公告)日: 2011-07-12
- 发明人: Kenji Kawashima , Hiroshi Enomoto , Noriko Ishizaka , Minoru Yamamoto , Kazuhiro Kudou , Masaaki Murai , Takaaki Inaba , Kazuyoshi Okamoto
- 申请人: Kenji Kawashima , Hiroshi Enomoto , Noriko Ishizaka , Minoru Yamamoto , Kazuhiro Kudou , Masaaki Murai , Takaaki Inaba , Kazuyoshi Okamoto
- 申请人地址: JP Osaka-Shi, Osaka
- 专利权人: Santen Pharmaceutical Co., Ltd.
- 当前专利权人: Santen Pharmaceutical Co., Ltd.
- 当前专利权人地址: JP Osaka-Shi, Osaka
- 代理机构: Holtz, Holtz, Goodman & Chick, PC
- 优先权: JP2007-045582 20070226
- 国际申请: PCT/JP2008/053297 WO 20080226
- 国际公布: WO2008/105408 WO 20080904
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; A61K31/497 ; A61K31/496 ; A61K31/454 ; A61K31/4439 ; A61K31/427 ; A61K31/422 ; A61K31/403 ; A61K31/4025 ; A61K31/40 ; C07D417/12 ; C07D413/12 ; C07D409/04 ; C07D405/12 ; C07D407/10 ; C07D401/12 ; C07D401/04 ; C07D403/12 ; C07D403/10
摘要:
Objects of the present invention are to study on the synthesis of a novel pyrrole derivative having a ureido group and an aminocarbonyl group as substituents or a salt thereof, to find a pharmacological effect of the derivative or a salt thereof, and to find a medicinal agent which has a prophylactic and/or therapeutic effect on a retinal disease or the like through oral administration. A compound represented by the general formula (1) or a salt thereof has an inhibitory activity against the production of interleukin-6 and/or an inhibitory effect on choroidal neovascularization, and is therefore useful as a prophylactic and/or therapeutic agent for a disease associated with interleukin-6, an ocular inflammatory disease and/or a retinal disease. In the formula, the ring A represents a benzene ring or the like; R1 represents a halogen atom, a hydrogen atom, a lower alkyl group or the like; R2 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group, a lower alkynyl group which may have a substituent, a lower cycloalkyl group, an aryl group, a hydroxy group, a lower alkoxy group which may have a substituent or the like; and n represents 0, 1, 2, 3 or the like.
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