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12 条记录 (耗时 0.02 秒)

    Indole derivative having, carbamoyl group, ureido group and substituted oxy group
    1.
    发明授权
    Indole derivative having, carbamoyl group, ureido group and substituted oxy group 失效
    具有氨基甲酰基，脲基和取代氧基的吲哚衍生物

    公开(公告)号：US08445529B2

    公开(公告)日：2013-05-21

    申请号：US13054041

    申请日：2009-07-14

    申请人： Kenji Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

    发明人： Kenji Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

    IPC分类号： A61K31/404 ,  C07D209/40

    CPC分类号： C07D209/42 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04

    摘要： An indole compound having a carbamoyl group, a ureido group and a substituted oxy group having the following formula (1) or a salt thereof: In the formula (1), R1 represents a hydrogen atom, an alkyl group, a hydroxy group, or an alkoxy group; R2 represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group, or a heterocyclic group; R3 represents a halogen atom, an alkyl group, an alkenyl group, an alkynyl group, a cycloalkyl group, an aryl group, a heterocyclic group an alkoxy group, an alkenyloxy group, an alkynyloxy group, a cycloalkyloxy group, an aryloxy group or a heterocyclic oxy group; m represents 0, 1, 2, or 3.

    摘要翻译： 具有氨基甲酰基，脲基和具有下式（1）的取代的氧基的吲哚化合物或其盐：在式（1）中，R 1表示氢原子，烷基，羟基或 烷氧基 R2表示氢原子，烷基，环烷基，芳基或杂环基; R3表示卤素原子，烷基，烯基，炔基，环烷基，芳基，杂环基，烷氧基，烯氧基，炔氧基，环烷氧基，芳氧基或 杂环氧基; m表示0,1,2或3。

    Time division communication system adapted to structural expansion
    3.
    发明授权
    Time division communication system adapted to structural expansion 失效
    时分通信系统适应结构扩展

    公开(公告)号：US4028495A

    公开(公告)日：1977-06-07

    申请号：US645069

    申请日：1975-12-29

    申请人： Hiroshi Funamo ,  Toshiro Kunihiro ,  Masaaki Murai

    发明人： Hiroshi Funamo ,  Toshiro Kunihiro ,  Masaaki Murai

    IPC分类号： H04Q3/52 ,  H04J3/00 ,  H04Q11/04 ,  H04M3/00

    CPC分类号： H04Q11/0407

    摘要： A time division communication system is constructed with modular time division switches. The system includes 2n switch modules (n is a positive integer), and each switch module is composed of m line control units (m is a positive integer) for accomodating m lines and a time division switch control unit capable of controlling 2m line control units. The switch modules are assembled in pairs, and cross connections are provided between the switch modules of each pair to enable the respective time division switch control units to mutually send and receive time-division multiplexed information. In addition, the input and output terminals of the corresponding time division switch control units of the respective switch module pairs are interconnected so that respective ones of the module pairs may mutually send and receive time-division multiplexed information.

    摘要翻译： 时分通信系统采用模块化时分交换机构成。 该系统包括2n个开关模块（n为正整数），并且每个开关模块由用于容纳m线的m个线路控制单元（m为正整数）组成，并且能够控制2m线路控制单元的时分开关控制单元 。 交换机模块成对组装，并且在每对的交换机模块之间提供交叉连接，以使得相应的时分交换控制单元能够相互发送和接收时分多路复用信息。 另外，相应的开关模块对的相应的时分开关控制单元的输入和输出端互连，使得模块对中的各个可以相互发送和接收时分多路复用信息。

    Angiogenesis inhibitor
    4.
    发明授权
    Angiogenesis inhibitor 失效
    血管生成抑制剂

    公开(公告)号：US07741346B2

    公开(公告)日：2010-06-22

    申请号：US10497223

    申请日：2002-11-29

    申请人： Hidehito Matsuoka ,  Kazuo Nishimura ,  Hisayuki Seike ,  Hiroyuki Aono ,  Masaaki Murai

    发明人： Hidehito Matsuoka ,  Kazuo Nishimura ,  Hisayuki Seike ,  Hiroyuki Aono ,  Masaaki Murai

    IPC分类号： A61K31/44 ,  C07D213/0025

    CPC分类号： C07D213/40 ,  A61K31/4409 ,  C07D213/32 ,  C07D213/56 ,  Y02P20/582

    摘要： An object of the present invention is to find new pharmacological actions of urea compounds having structure represented by the general formula [1]. The urea compounds having the structure represented by the general formula [1] have excellent angiogenesis inhibitory actions. [wherein “A” is —(NR4)—, —(CR5R6)— or —O—, “B” is alkylene or alkenylene, R1, R2, R4, R5 and R6 are hydrogen, alkyl, alkenyl, adamantylalkyl or the like, R3 is aryl or an unsaturated heterocycle, and X is oxygen or sulfur].

    摘要翻译： 本发明的目的是找到具有由通式[1]表示的结构的尿素化合物的新的药理作用。 具有由通式[1]表示的结构的脲化合物具有优异的血管发生抑制作用。 [其中“A”是 - （NR4） - ， - （CR5R6） - 或-O-，“B”是亚烷基或亚烯基，R1，R2，R4，R5和R6是氢，烷基，烯基，金刚烷基烷基等 ，R3为芳基或不饱和杂环，X为氧或硫]。

    NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP
    7.
    发明申请
    NOVEL INDOLE DERIVATIVE HAVING, CARBAMOYL GROUP, UREIDO GROUP AND SUBSTITUTED OXY GROUP 失效
    新加坡衍生产品有限公司，卡巴集团，乌代组和替代氧化集团

    公开(公告)号：US20110124668A1

    公开(公告)日：2011-05-26

    申请号：US13054041

    申请日：2009-07-14

    申请人： Kenji Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

    发明人： Kenji Kawashima ,  Hiroshi Enomoto ,  Minoru Yamamoto ,  Masaaki Murai

    IPC分类号： A61K31/404 ,  C07D209/42 ,  C07D403/12 ,  A61K31/506 ,  C07D401/12 ,  A61K31/4439 ,  C07D405/10 ,  A61P29/00 ,  A61P27/06 ,  A61P17/00 ,  A61P27/02 ,  A61P35/00 ,  A61P3/00 ,  A61P25/00 ,  A61P37/06 ,  A61P31/00 ,  A61P37/08

    CPC分类号： C07D209/42 ,  A61K31/404 ,  A61K31/4439 ,  A61K31/506 ,  C07D401/12 ,  C07D403/12 ,  C07D405/04

    摘要： The present invention relates to synthetic studies on novel indole derivatives having a carbamoyl group, a ureido group and a substituted oxy group or a salt thereof, and pharmaceutical actions of the derivatives. The compound and a salt thereof represented by the general formula (1) has an IKKβ inhibitory activity and is useful as a preventive and/or therapeutic agent for diseases considered to be associated with IKKβ. In the formula, R1 represents a hydrogen atom, a lower alkyl group which may have a substituent, a hydroxy group, or a lower alkoxy group which may have a substituent, or the like; R2 represents a hydrogen atom, a lower alkyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, or a heterocyclic group which may have a substituent, or the like; R3 represents a halogen atom, a lower alkyl group which may have a substituent, a lower alkenyl group which may have a substituent, a lower alkynyl group which may have a substituent, a lower cycloalkyl group which may have a substituent, an aryl group which may have a substituent, a heterocyclic group which may have a substituent, or the like; m represents 0, 1, 2, or the like.

    摘要翻译： 本发明涉及具有氨基甲酰基，脲基和取代的氧基或其盐的新型吲哚衍生物的合成研究以及衍生物的药物作用。 由通式（1）表示的化合物及其盐具有IKK＆bgr; 抑制活性，并且可用作被认为与IKK＆bgr相关的疾病的预防和/或治疗剂。 式中，R 1表示氢原子，可以具有取代基的低级烷基，羟基或可具有取代基的低级烷氧基等。 R2表示氢原子，可以具有取代基的低级烷基，可以具有取代基的低级环烷基，可以具有取代基的芳基或可以具有取代基的杂环基等。 R3表示卤原子，可以具有取代基的低级烷基，可以具有取代基的低级烯基，可以具有取代基的低级炔基，可以具有取代基的低级环烷基，可以具有取代基的低级环烷基， 可以具有取代基，可以具有取代基的杂环基等; m表示0,1,2等。

    THERAPEUTIC AGENT FOR TRPV1-MEDIATED DISEASE
    8.
    发明申请
    THERAPEUTIC AGENT FOR TRPV1-MEDIATED DISEASE 审中-公开
    TRPV1介导性疾病治疗药物

    公开(公告)号：US20100261911A1

    公开(公告)日：2010-10-14

    申请号：US12682090

    申请日：2008-10-16

    申请人： Kenji Oki ,  Fumio Tsuji ,  Chikako Setoguchi ,  Iwao Seki ,  Masaaki Murai ,  Minoru Sasano

    发明人： Kenji Oki ,  Fumio Tsuji ,  Chikako Setoguchi ,  Iwao Seki ,  Masaaki Murai ,  Minoru Sasano

    IPC分类号： C07D213/40

    CPC分类号： A61K31/4409 ,  A61K31/44 ,  C07D213/36

    摘要： An object of the present invention is to find a novel pharmacological action of a urea compound having a structure represented by the general formula [I]. The urea compound having a structure represented by the general formula [I] or a salt thereof has an excellent therapeutic effect on a TRPV1-mediated disease. In the formula, A represents a lower alkylene group or a lower alkenylene group; R1 represents a hydrogen atom, an alkyl group which may have a substituent or an alkenyl group which may have a substituent; and R2 and R3 are the same or different and represent a hydrogen atom or a lower alkyl group which may be substituted by a monocyclic cycloalkyl group, a polycyclic cycloalkyl group, or an aryl group.

    摘要翻译： 本发明的目的是找到具有由通式[I]表示的结构的尿素化合物的新药理作用。 具有由通式[I]表示的结构的脲化合物或其盐对TRPV1介导的疾病具有优异的治疗作用。 在该式中，A表示低级亚烷基或低级亚烯基; R1表示氢原子，可以具有取代基的烷基或可具有取代基的烯基; R2和R3相同或不同，表示氢原子或可被单环环烷基，多环环烷基或芳基取代的低级烷基。