- 专利标题: Rage fusion proteins
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申请号: US11629437申请日: 2005-08-03
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公开(公告)号: US07981423B2公开(公告)日: 2011-07-19
- 发明人: Adnan M. M. Mjalli , Ye E. Tian , Jeffrey C. Webster , Robert Rothlein
- 申请人: Adnan M. M. Mjalli , Ye E. Tian , Jeffrey C. Webster , Robert Rothlein
- 申请人地址: US NC High Point
- 专利权人: Transtech Pharma, Inc.
- 当前专利权人: Transtech Pharma, Inc.
- 当前专利权人地址: US NC High Point
- 代理机构: Kilpatrick Townsend & Stockton LLP
- 国际申请: PCT/US2005/027705 WO 20050803
- 国际公布: WO2006/017647 WO 20060216
- 主分类号: A61K39/00
- IPC分类号: A61K39/00 ; C12P21/00 ; A61K38/16
摘要:
Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
公开/授权文献
- US20080075733A1 Rage Fusion Proteins And Method Of Use 公开/授权日:2008-03-27