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公开(公告)号：US20130142792A1
公开(公告)日：2013-06-06
申请号：US13062395
申请日：2010-10-19
申请人： Jeffrey C. Webster , Gregory T. Bleck , Madan Katragadda , Manoj Rajadhyaksha , Bernard N. Violand , Jo-Ann Wentland , Linda Marie Rothlein
发明人： Robert Rothlein , Jeffrey C. Webster , Gregory T. Bleck , Madan Katragadda , Manoj Rajadhyaksha , Bernard N. Violand , Jo-Ann Wentland
IPC分类号： C07K14/705 , C07K16/00
CPC分类号： C07K14/70503 , A61K39/00 , C07K16/00 , C12N15/62
摘要： Disclosed are fusion proteins comprising a RAGE polypeptide, wherein the RAGE polypeptide comprises a fragment of a mammalian wild type RAGE peptide and at least one point mutation in the RAGE polypeptide portion of the fusion protein relative to the wild type RAGE peptide. The point mutation may remove and/or alter a glycosylation site or an enzyme cleavage site. Also disclosed are nucleic acids encoding such proteins as well as methods of using such proteins for treating RAGE-mediated pathologies.
摘要翻译： 公开了包含RAGE多肽的融合蛋白，其中RAGE多肽包含哺乳动物野生型RAGE肽的片段和融合蛋白的RAGE多肽部分相对于野生型RAGE肽的至少一个点突变。 点突变可以去除和/或改变糖基化位点或酶切割位点。 还公开了编码这种蛋白质的核酸以及使用这些蛋白质治疗RAGE介导的病理学的方法。
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公开(公告)号：US08344120B2
公开(公告)日：2013-01-01
申请号：US13158748
申请日：2011-06-13
IPC分类号： C07H21/04
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/30 , C12N15/62
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点的RAGE多肽结构域和直接连接到免疫球蛋白CH2结构域的N末端的域间连接。 还公开了RAGE融合蛋白制剂以及使用RAGE融合蛋白和RAGE融合蛋白制剂作为RAGE介导的病理学的治疗剂。
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公开(公告)号：US20110244516A1
公开(公告)日：2011-10-06
申请号：US13029622
申请日：2011-02-17
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
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公开(公告)号：US07981424B2
公开(公告)日：2011-07-19
申请号：US11789637
申请日：2007-04-25
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/30 , C12N15/62
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点的RAGE多肽结构域和直接连接到免疫球蛋白CH2结构域的N末端的域间连接。 还公开了RAGE融合蛋白制剂以及使用RAGE融合蛋白和RAGE融合蛋白制剂作为RAGE介导的病理学的治疗剂。
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公开(公告)号：US07981423B2
公开(公告)日：2011-07-19
申请号：US11629437
申请日：2005-08-03
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
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公开(公告)号：US20080199467A1
公开(公告)日：2008-08-21
申请号：US12069499
申请日：2008-02-11
CPC分类号： C12N15/62 , C07K2319/30
摘要： Disclosed are immunoglobulin fusion proteins and methods of making such proteins. In certain embodiments, the fusion protein may include a non-immunoglobulin polypeptide linked to an immunoglobulin polypeptide. In certain embodiments, the non-immunoglobulin polypeptide may comprise a region that replaces an immunoglobulin Fc hinge region, but that allows for correct assembly of the immunoglobulin chains.
摘要翻译： 公开了免疫球蛋白融合蛋白和制备这些蛋白质的方法。 在某些实施方案中，融合蛋白可包括与免疫球蛋白多肽连接的非免疫球蛋白多肽。 在某些实施方案中，非免疫球蛋白多肽可以包含替代免疫球蛋白Fc铰链区但允许免疫球蛋白链的正确装配的区域。
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公开(公告)号：US20120171202A1
公开(公告)日：2012-07-05
申请号：US12983604
申请日：2011-01-03
IPC分类号： A61K39/395 , A61P25/00 , A61P25/28 , A61P35/00 , A61P1/00 , A61P29/00 , A61P17/06 , A61P7/00 , A61P9/10 , A61P9/04 , A61P37/06 , A61P17/02 , A61P13/12 , A61P27/02 , A61P3/10
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点和直接连接到免疫球蛋白CH2结构域的域间连接体的RAGE多肽结构域。 这样的融合蛋白可以提供与RAGE配体的特异的高亲和力结合。 还公开了RAGE融合蛋白作为RAGE介导的病理学的治疗剂的用途。
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公开(公告)号：US20110282035A1
公开(公告)日：2011-11-17
申请号：US13158748
申请日：2011-06-13
CPC分类号： C07K14/70503 , A61K38/00 , C07K2319/30 , C12N15/62
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to the N-terminus of an immunoglobulin CH2 domain. Also disclosed are RAGE fusion protein formulations and the use of the RAGE fusion proteins and RAGE fusion protein formulations as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点的RAGE多肽结构域和直接连接到免疫球蛋白CH2结构域的N末端的域间连接。 还公开了RAGE融合蛋白制剂以及使用RAGE融合蛋白和RAGE融合蛋白制剂作为RAGE介导的病理学的治疗剂。
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公开(公告)号：US20090060925A1
公开(公告)日：2009-03-05
申请号：US11630916
申请日：2005-08-03
申请人： Adnan M.M. Mjalli , Ye Edward Tian , Jeffrey C. Webster , Robert Rothlein , David M. Stern , Ann Marie Schmidt , Shi Du Yan
发明人： Adnan M.M. Mjalli , Ye Edward Tian , Jeffrey C. Webster , Robert Rothlein , David M. Stern , Ann Marie Schmidt , Shi Du Yan
IPC分类号： A61K39/395 , C07K14/00 , C07K16/00 , C12N15/63 , A61P3/10 , A61P25/28 , A61P29/00 , A61P13/12 , A61P35/00 , A61P9/00 , G01N33/53 , C07H21/00 , A61K38/16
CPC分类号： C07K16/2803 , A61K38/00 , C07K14/705 , C07K2319/30 , G01N33/6893 , G01N33/6896 , G01N2500/00 , G01N2800/042
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点和直接连接到免疫球蛋白CH2结构域的域间连接体的RAGE多肽结构域。 这样的融合蛋白可以提供与RAGE配体的特异的高亲和力结合。 还公开了RAGE融合蛋白作为RAGE介导的病理学的治疗剂的用途。
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公开(公告)号：US08877192B2
公开(公告)日：2014-11-04
申请号：US12983604
申请日：2011-01-03
IPC分类号： A61K38/00 , C07K14/705
CPC分类号： C07K14/705 , A61K38/00
摘要： Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
摘要翻译： 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点和直接连接到免疫球蛋白CH2结构域的域间连接体的RAGE多肽结构域。 这样的融合蛋白可以提供与RAGE配体的特异的高亲和力结合。 还公开了RAGE融合蛋白作为RAGE介导的病理学的治疗剂的用途。
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