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公开(公告)号:US07981423B2
公开(公告)日:2011-07-19
申请号:US11629437
申请日:2005-08-03
CPC分类号: C07K14/705 , A61K38/00
摘要: Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
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公开(公告)号:US20090004190A1
公开(公告)日:2009-01-01
申请号:US12162658
申请日:2007-01-23
IPC分类号: A61K39/395 , A61P37/00
CPC分类号: C07K14/70503 , A61B5/0059 , A61B5/4088 , A61B5/412 , A61B5/413 , C07K2319/30 , C07K2319/32 , C07K2319/70 , G01J3/4412 , G01N21/4795 , G01N2021/638 , G01N2800/042 , G01N2800/387
摘要: Disclosed are RAGE fusion proteins comprising RAGE polypeptide sequences linked to a second, non-RAGE polypeptide. The RAGE fusion protein may utilize a RAGE polypeptide domain comprising a RAGE ligand binding site and an interdomain linker directly linked to an immunoglobulin CH2 domain. Such fusion proteins may provide specific, high affinity binding to RAGE ligands. Also disclosed is the use of the RAGE fusion proteins as therapeutics for RAGE-mediated pathologies.
摘要翻译: 公开了包含与第二非RAGE多肽连接的RAGE多肽序列的RAGE融合蛋白。 RAGE融合蛋白可以利用包含RAGE配体结合位点和直接连接到免疫球蛋白CH2结构域的域间连接体的RAGE多肽结构域。 这样的融合蛋白可以提供与RAGE配体的特异的高亲和力结合。 还公开了RAGE融合蛋白作为RAGE介导的病理学的治疗剂的用途。
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3.
公开(公告)号:US07820704B2
公开(公告)日:2010-10-26
申请号:US11110499
申请日:2005-04-20
申请人: Adnan M. M. Mjalli , Bapu R. Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty N. Arimilli , Robert C. Andrews , Samuel Victory , Ye E. Tian
发明人: Adnan M. M. Mjalli , Bapu R. Gaddam , Ghassan Qabaja , Govindan Subramanian , Jeff Zhu , John Dankwardt , Murty N. Arimilli , Robert C. Andrews , Samuel Victory , Ye E. Tian
IPC分类号: A61K31/427 , A61K31/381 , C07D277/38 , C07D409/12
CPC分类号: C07D277/52 , C07D239/42 , C07D277/26 , C07D277/42 , C07D277/50 , C07D277/56 , C07D277/82 , C07D403/12 , C07D405/12 , C07D409/12 , C07D417/04 , C07D417/12 , C07D417/14
摘要: The present invention provides substituted heteroaryl derivatives of Formula (I), methods of their preparation, pharmaceutical compositions comprising the compounds of Formula (I), and methods of use in treating human or animal disorders. The compounds of the invention can be useful as inhibitors of action of AgRP on a melanocortin receptor and thus can be useful for the management, treatment, control, or the adjunct treatment of diseases which may be responsive to the modulation of melanocortin receptors including obesity-related disorders.
摘要翻译: 本发明提供式(I)的取代杂芳基衍生物,其制备方法,包含式(I)化合物的药物组合物,以及用于治疗人或动物病症的方法。 本发明的化合物可用作AgRP对黑皮质素受体的作用抑制剂,因此可用于治疗,治疗,控制或辅助治疗可能对黑皮质素受体的调节(包括肥胖症 - 相关疾病。
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