发明授权
US07981868B2 Antisense modulation of p38 mitogen activated protein kinase expression
失效
p38丝裂原活化蛋白激酶表达的反义调制
- 专利标题: Antisense modulation of p38 mitogen activated protein kinase expression
- 专利标题(中): p38丝裂原活化蛋白激酶表达的反义调制
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申请号: US10568488申请日: 2004-08-12
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公开(公告)号: US07981868B2公开(公告)日: 2011-07-19
- 发明人: Brett P. Monia , Kenneth W. Dobie , Susan M. Freier , Ian Popoff , James G. Karras
- 申请人: Brett P. Monia , Kenneth W. Dobie , Susan M. Freier , Ian Popoff , James G. Karras
- 申请人地址: US CA Carlsbad
- 专利权人: Isis Pharmaceuticals, Inc.
- 当前专利权人: Isis Pharmaceuticals, Inc.
- 当前专利权人地址: US CA Carlsbad
- 代理机构: Knobbe, Martens, Olson & Bear LLP
- 国际申请: PCT/US2004/026344 WO 20040812
- 国际公布: WO2005/016947 WO 20050224
- 主分类号: C07H21/00
- IPC分类号: C07H21/00 ; C07H21/02 ; C12N15/11 ; A61K48/00
摘要:
Compositions and methods for the treatment and diagnosis of diseases or conditions amenable to treatment through modulation of expression of a gene encoding a p38 mitogen-activated protein kinase (p38 MAPK) are provided. Methods for decreasing airway hyperresponsiveness or airway inflammation in an animal are also provided.
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