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13 条记录 (耗时 0.019 秒)

    Antisense oligonucleotides and RNA-interfering molecules targeting PAK4
    4.
    发明申请
    Antisense oligonucleotides and RNA-interfering molecules targeting PAK4 审中-公开
    靶向PAK4的反义寡核苷酸和RNA干扰分子

    公开(公告)号：US20050191672A1

    公开(公告)日：2005-09-01

    申请号：US11045182

    申请日：2005-01-27

    申请人： Ian Popoff ,  Todd Van Arsdale

    发明人： Ian Popoff ,  Todd Van Arsdale

    IPC分类号： A61K48/00 ,  C07H21/02 ,  C12N15/113 ,  C12Q1/68

    CPC分类号： C12N15/1137 ,  C07H21/02 ,  C12N2310/11 ,  C12N2310/14 ,  C12Y207/01037

    摘要： Compositions and methods for modulating the expression of the serine/threonine kinase PAK4 are provided. In particular, the invention relates to antisense compounds, particularly oligonucleotides and double-stranded RNA molecules, which specifically hybridize to nucleic acid molecules encoding PAK4. The oligonucleotides and RNA molecules decrease or inhibit PAK4 expression and thus, can be used in target identification and/or validation, to examine PAK4 pathways and the cellular effects of PAK4 expression, and to diagnose and/or treat abnormal cell growth or inflammation associated with PAK4 expression.

    摘要翻译： 提供了调节丝氨酸/苏氨酸激酶PAK4表达的组合物和方法。 特别地，本发明涉及与编码PAK4的核酸分子特异性杂交的反义化合物，特别是寡核苷酸和双链RNA分子。 寡核苷酸和RNA分子降低或抑制PAK4表达，因此可用于靶标鉴定和/或验证，以检查PAK4途径和PAK4表达的细胞效应，并诊断和/或治疗异常细胞生长或与 PAK4表达。

    Antisense modulation of damage-specific DNA binding protein 2, p48 expression
    5.
    发明授权
    Antisense modulation of damage-specific DNA binding protein 2, p48 expression 有权
    损伤特异性DNA结合蛋白2，p48表达的反义调制

    公开(公告)号：US06379960B1

    公开(公告)日：2002-04-30

    申请号：US09732199

    申请日：2000-12-06

    申请人： Ian Popoff ,  Jacqueline Wyatt

    发明人： Ian Popoff ,  Jacqueline Wyatt

    IPC分类号： C12Q168

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Damage-specific DNA binding protein 2, p48. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Damage-specific DNA binding protein 2, p48. Methods of using these compounds for modulation of Damage-specific DNA binding protein 2, p48 expression and for treatment of diseases associated with expression of Damage-specific DNA binding protein 2, p48 are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节损伤特异性DNA结合蛋白2，p48的表达。 组合物包含靶向编码损伤特异性DNA结合蛋白2，p48的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节损伤特异性DNA结合蛋白2，p48表达和治疗与损伤特异性DNA结合蛋白2，p48表达有关的疾病的方法。

    Antisense modulation of damage-specific DNA binding protein 1, p127 expression
    9.
    发明授权
    Antisense modulation of damage-specific DNA binding protein 1, p127 expression 失效
    反义调制损伤特异性DNA结合蛋白1，p127表达

    公开(公告)号：US06855700B2

    公开(公告)日：2005-02-15

    申请号：US09731457

    申请日：2000-12-06

    申请人： Ian Popoff ,  Jacqueline Wyatt

    发明人： Ian Popoff ,  Jacqueline Wyatt

    IPC分类号： A61K38/00 ,  C12N15/113 ,  A61K41/00 ,  C07H21/04

    CPC分类号： C12N15/113 ,  A61K38/00 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  Y02P20/582 ,  C12N2310/3525

    摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Damage-specific DNA binding protein 1, p127. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Damage-specific DNA binding protein 1, p127. Methods of using these compounds for modulation of Damage-specific DNA binding protein 1, p127 expression and for treatment of diseases associated with expression of Damage-specific DNA binding protein 1, p127 are provided.

    摘要翻译： 提供反义化合物，组合物和方法用于调节损伤特异性DNA结合蛋白1，p127的表达。 组合物包含靶向编码损伤特异性DNA结合蛋白1，p127的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节损伤特异性DNA结合蛋白1，p127表达和治疗与损伤特异性DNA结合蛋白1，p127表达相关疾病的方法。