- 专利标题： Monomethylvaline compounds capable of conjugation to ligands
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申请号： US11833954申请日： 2007-08-03
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公开(公告)号： US07994135B2公开(公告)日： 2011-08-09
- 发明人: Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
- 申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
- 申请人地址： US WA Bothell
- 专利权人： Seattle Genetics, Inc.
- 当前专利权人： Seattle Genetics, Inc.
- 当前专利权人地址： US WA Bothell
- 代理机构： Kilpatrick Townsend & Stockton LLP
- 主分类号： A61K38/00
- IPC分类号： A61K38/00 ; A61K38/02 ; C07K2/00
摘要：
Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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