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公开(公告)号：US20120141509A1
公开(公告)日：2012-06-07
申请号：US13397654
申请日：2012-02-15
申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号： A61K39/395 , A61P35/00 , C07K16/00
CPC分类号： C07K16/32 , A61K38/00 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y10T428/13
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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公开(公告)号：US20120141508A1
公开(公告)日：2012-06-07
申请号：US13397650
申请日：2012-02-15
申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号： A61K39/395 , A61P35/00 , C07K16/00
CPC分类号： C07K16/32 , A61K38/00 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y10T428/13
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
摘要翻译： 制备包括MeVal-Val-Dil-Dap-Norephedrine（MMAE）和MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽，并通过各种接头包括马来酰亚胺酰基val-cit-PAB连接到配体上。 所得配体药物偶联物在体外和体内都是活性的。
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公开(公告)号：US08163287B2
公开(公告)日：2012-04-24
申请号：US11490438
申请日：2006-07-19
IPC分类号： A61K39/395 , A01N43/42 , A01N43/54 , C07D239/72
CPC分类号： C07K16/32 , A61K31/517 , A61K31/7068 , A61K39/395 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07D239/86 , C07D239/94 , C07K16/2863 , C07K2317/24 , C07K2317/76 , A61K2300/00
摘要： The invention relates to tumors expressing HER2 and EGFR, using HER2-dimerization inhibitors (HDIs) and EGFR inhibitors.
摘要翻译： 本发明涉及使用HER2-二聚抑制剂（HDI）和EGFR抑制剂表达HER2和EGFR的肿瘤。
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公开(公告)号：US20120034247A1
公开(公告)日：2012-02-09
申请号：US13189456
申请日：2011-07-22
申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号： A61K39/395 , A61P35/00 , C07K16/18
CPC分类号： C07K16/32 , A61K38/00 , A61K47/6803 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y10T428/13
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
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公开(公告)号：US07919254B2
公开(公告)日：2011-04-05
申请号：US12688691
申请日：2010-01-15
CPC分类号： C12Q1/6841 , C12Q1/6804 , C12Q1/6886 , C12Q2600/156 , G01N33/57415 , G01N33/57492 , G01N33/582 , G01N33/6872 , G01N2333/71 , C12Q2563/131
摘要： This invention relates to methods of analyzing a tissue sample from a subject. In particular, the invention combines morphological staining and/or immunohistochemistry (IHC) with fluorescence in situ hybridization (FISH) within the same section of a tissue sample. The analysis can be automated or manual. The invention also relates to kits for use in the above methods.
摘要翻译： 本发明涉及从受试者分析组织样本的方法。 特别地，本发明将形态学染色和/或免疫组织化学（IHC）与组织样品的同一部分内的荧光原位杂交（FISH）相结合。 分析可以是自动的或手动的。 本发明还涉及用于上述方法的试剂盒。
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公开(公告)号：US20090068205A1
公开(公告)日：2009-03-12
申请号：US12215200
申请日：2008-06-24
IPC分类号： A61K39/395 , A61K31/7088 , A61P9/12 , C12Q1/68 , C07K16/28
CPC分类号： C07K14/82 , A61K38/00 , C07K14/4756 , C07K16/32 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/00 , C07K2319/30 , G01N33/5061
摘要： The present invention concerns methods and means for controlling excessive proliferation and/or migration of smooth muscle cells, and in particular for treating stenosis, by using antagonists of a native ErbB4 receptor. The invention further concerns a method for the identification of ErbB4 agonists and antagonists capable of inhibiting or enhancing the proliferation or migration of smooth muscle cells.
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公开(公告)号：US20090047296A1
公开(公告)日：2009-02-19
申请号：US11833954
申请日：2007-08-03
申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K16/32 , A61K38/00 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y02A50/491 , Y02A50/492 , Y10T428/13
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
摘要翻译： 制备包括MeVal-Val-Dil-Dap-Norephedrine（MMAE）和MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽，并通过各种接头包括马来酰亚胺酰基val-cit-PAB连接到配体上。 所得配体药物偶联物在体外和体内都是活性的。
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公开(公告)号：US20080248053A1
公开(公告)日：2008-10-09
申请号：US11833959
申请日：2007-08-03
申请人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
发明人： Svetlana O. Doronina , Peter D. Senter , Brian E. Toki , Allen J. Ebens , Toni Beth Kline , Paul Polakis , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00
CPC分类号： C07K16/32 , A61K38/00 , A61K47/6811 , A61K47/6849 , A61K47/6851 , A61K47/6855 , A61K2039/505 , C07K7/02 , C07K2317/24 , Y02A50/414 , Y02A50/423 , Y02A50/469 , Y02A50/491 , Y02A50/492 , Y10T428/13
摘要： Auristatin peptides, including MeVal-Val-Dil-Dap-Norephedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), were prepared and attached to Ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
摘要翻译： 制备包括MeVal-Val-Dil-Dap-Norephedrine（MMAE）和MeVal-Val-Dil-Dap-Phe（MMAF）的Auristatin肽，并通过各种接头包括马来酰亚胺酰基val-cit-PAB连接到配体上。 所得配体药物偶联物在体外和体内都是活性的。
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公开(公告)号：US08597652B2
公开(公告)日：2013-12-03
申请号：US12728052
申请日：2010-03-19
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： A61K47/48569 , A61K2039/505 , A61K2039/507 , C07K16/28 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/92
摘要： The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.
摘要翻译： 本发明提供抗HER抗体，包括多特异性抗HER抗体，组合物和使用这些抗体的方法。 本文还提供了比传统EGFR拮抗剂毒性小的EGFR / HER3多特异性抗体。
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公开(公告)号：US08142784B2
公开(公告)日：2012-03-27
申请号：US12326721
申请日：2008-12-02
申请人： Allen J. Ebens, Jr. , Frederic S. Jacobson , Paul Polakis , Ralph H. Schwall , Mark X. Sliwkowski , Susan D. Spencer
发明人： Allen J. Ebens, Jr. , Frederic S. Jacobson , Paul Polakis , Ralph H. Schwall , Mark X. Sliwkowski , Susan D. Spencer
IPC分类号： A61K39/395
CPC分类号： A61K47/48569 , A61K47/6803 , A61K47/6875 , A61K2039/505 , C07D498/18 , C07K16/1063 , C07K16/28 , C07K16/2803 , C07K16/283 , C07K16/2866 , C07K16/2896 , C07K16/3046 , C07K16/3069 , C07K16/32 , C07K2317/24
摘要： The present invention relates to antibody-drug conjugate compounds of Formula I: Ab-(L-D)p I where one or more maytansinoid drug moieties (D) are covalently linked by L to an antibody (Ab) which binds to an ErbB receptor, or which binds to one or more tumor-associated antigens or cell-surface receptors. These compounds may be used in methods of diagnosis or treatment of cancer, and other diseases and disorders.
摘要翻译： 本发明涉及式I的抗体 - 药物偶联化合物：Ab-（LD）p I，其中一种或多种美登木素生物碱药物部分（D）通过L共价连接到结合ErbB受体的抗体（Ab），或 其结合一种或多种肿瘤相关抗原或细胞表面受体。 这些化合物可用于诊断或治疗癌症及其它疾病和病症的方法中。
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