发明授权
- 专利标题： Bicyclic anilide spirolactam CGRP receptor antagonists
- 专利标题（中）： 双环苯胺己内酰胺CGRP受体拮抗剂
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申请号： US11662703申请日： 2005-09-09
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公开(公告)号： US08003792B2公开(公告)日： 2011-08-23
- 发明人: Ian M. Bell , Cory R. Theberge , Craig A. Stump , Xufang Zhang , Steven N. Gallicchio , C. Blair Zartman
- 申请人： Ian M. Bell , Cory R. Theberge , Craig A. Stump , Xufang Zhang , Steven N. Gallicchio , C. Blair Zartman
- 申请人地址： US NJ Rahway
- 专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人： Merck Sharp & Dohme Corp.
- 当前专利权人地址： US NJ Rahway
- 代理商 Gerard Devlin; Raynard Yuro
- 国际申请： PCT/US2005/032041 WO 20050909
- 国际公布： WO2006/031610 WO 20060323
- 主分类号： A61K31/40
- IPC分类号： A61K31/40 ; A61K31/438 ; C07D401/04 ; C07D227/02
摘要：
The present invention is directed to compounds of Formula I: (where variables A1, A2, B, J, K, m, n, R4, R5a, R5b and R5c are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
公开/授权文献
- US20080096878A1 Bicyclic Anilide Spirolactam Cgrp Receptor Antagonists 公开/授权日：2008-04-24
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