Invention Grant
US08008250B2 Macrocyclic compounds and compositions useful as BACE inhibitors
失效
可用作BACE抑制剂的大环化合物和组合物
- Patent Title: Macrocyclic compounds and compositions useful as BACE inhibitors
- Patent Title (中): 可用作BACE抑制剂的大环化合物和组合物
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Application No.: US11794412Application Date: 2006-01-13
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Publication No.: US08008250B2Publication Date: 2011-08-30
- Inventor: Andreas Lerchner , Rainer Machauer , Marina Tintelnot-Blomley , Oliver Simic
- Applicant: Andreas Lerchner , Rainer Machauer , Marina Tintelnot-Blomley , Oliver Simic
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Strain & Strain PLLC
- Agent Paul D. Strain
- Priority: GB0500683.8 20050113
- International Application: PCT/EP2006/000265 WO 20060113
- International Announcement: WO2006/074940 WO 20060720
- Main IPC: A61K31/551
- IPC: A61K31/551 ; C07D243/00 ; C07K7/50
Abstract:
Macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them are presented.
Public/Granted literature
- US20080214526A1 Macrocyclic Compounds and Compositions Useful as Bace Inhibitors Public/Granted day:2008-09-04
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