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    PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS
    6.
    发明申请
    PYRROLIDINE DERIVATIVES USEFUL AS BACE INHIBITORS 审中-公开
    吡咯烷衍生物有效用作BACE抑制剂

    公开(公告)号：US20090247577A1

    公开(公告)日：2009-10-01

    申请号：US12303495

    申请日：2007-06-04

    申请人： Olivier Rogel ,  Jean-Michel Rondeau ,  Heinrich Rueeger ,  Oliver Simic ,  Finton Sirockin ,  Marina Tintelnot-Blomley

    发明人： Olivier Rogel ,  Jean-Michel Rondeau ,  Heinrich Rueeger ,  Oliver Simic ,  Finton Sirockin ,  Marina Tintelnot-Blomley

    IPC分类号： A61K31/4709 ,  C07D401/12

    CPC分类号： C07D215/48

    摘要： Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (disorder) that depends on the activity of beta-secretase and/or the generation of beta-amyloid and the subsequent aggregation into oligomers and fibrils; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on the activity of beta-secretase and/or the generation of beta-amyloid and the subsequent aggregation into oligomers and fibrils; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound. The substituted pyrrolidine compounds are especially of the formula I, wherein the substituents are as defined in the specification.

    摘要翻译： 新型3-单，3,4-二和3,4,4-三取代的吡咯烷化合物，用于诊断和治疗温血动物，特别是用于治疗疾病的化合物 （紊乱），其取决于β-分泌酶的活性和/或β-淀粉样蛋白的产生，并随后聚集成低聚物和原纤维; 使用该类化合物来制备用于治疗依赖于β-分泌酶的活性和/或产生β-淀粉样蛋白的疾病的药物制剂并随后聚集成低聚物和原纤维; 包含所述取代的吡咯烷化合物的药物制剂和/或包括施用所述取代的吡咯烷化合物的治疗方法。 取代的吡咯烷化合物特别是式I，其中取代基如说明书中所定义。