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公开(公告)号：US09284284B2
公开(公告)日：2016-03-15
申请号：US14350938
申请日：2012-10-11
Applicant: Konstanze Hurth , Sebastien Jacquier , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
Inventor： Konstanze Hurth , Sebastien Jacquier , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
IPC: C07D265/30 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04 , A61K31/5375 , A61K31/5377
CPC classification number: C07D265/30 , A61K31/5375 , A61K31/5377 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
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2.发明授权Oxazine derivatives and their use in the treatment of neurological disorders 有权恶嗪衍生物及其在治疗神经系统疾病中的应用公开(公告)号：US08207164B2
公开(公告)日：2012-06-26
申请号：US12842360
申请日：2010-07-23
Applicant: Philipp Holzer , Rainer Machauer , Marina Tintelnot-Blomley
Inventor： Philipp Holzer , Rainer Machauer , Marina Tintelnot-Blomley
IPC: A61K31/5377 , A61K31/5375 , C07D413/12 , C07D419/12 , C07D265/30 , A61P25/28
CPC classification number: C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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3.发明申请公开(公告)号：US20100056490A1
公开(公告)日：2010-03-04
申请号：US12500093
申请日：2009-07-09
Applicant: Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
Inventor： Emmanuelle Briard , Rainer Martin Lueoend , Rainer Machauer , Henrik Moebitz , Olivier Rogel , Jean-Michel Rondeau , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC: A61K31/397 , C07D401/12 , C07D205/02 , C07D335/02 , A61K31/4535 , A61K31/382 , A61P25/00 , A61P9/10
CPC classification number: C07D335/02 , C07D409/10 , C07D409/12 , C07D413/12 , C07F7/0812
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备方式，其用作药物和包含它们的药物。
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公开(公告)号：US20090312370A1
公开(公告)日：2009-12-17
申请号：US12374467
申请日：2007-07-20
Applicant: Kurt Laumen , Rainer Machauer , Marina Tintelnot-Blomley , Siem Jacob Veenstra
Inventor： Kurt Laumen , Rainer Machauer , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC: A61K31/4439 , C07D211/70 , A61K31/44 , C07D413/12
CPC classification number: C07D273/00 , C07D245/06 , C07D273/02 , C07D401/12 , C07D413/12 , C07D413/14
Abstract: The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型大环化合物，其中所有变量如本说明书中所定义，游离碱形式或酸加成盐形式，其制备方法，用作药物和包含它们的药物。
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5.发明申请OXAZINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开氧合物衍生物及其在治疗神经疾病中的应用公开(公告)号：US20150018338A1
公开(公告)日：2015-01-15
申请号：US14324883
申请日：2014-07-07
Applicant: Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LEUOEND , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Henrich RUEEGER , Michael SCHAEFER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
Inventor： Sangamesh BADIGER , Murali CHEBROLU , Mathias FREDERIKSEN , Philipp HOLZER , Konstanze HURTH , Rainer Martin LEUOEND , Rainer MACHAUER , Henrik MOEBITZ , Ulf NEUMANN , Rita RAMOS , Henrich RUEEGER , Michael SCHAEFER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC: C07D487/04 , A61K31/5377 , C07D413/14 , C07D471/04 , C07D417/12 , A61K31/553 , C07D413/12
CPC classification number: C07D487/04 , A61K31/5377 , A61K31/553 , A61K45/06 , C07D265/30 , C07D267/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, in free form or in salt form, to their preparation, to their medical use and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，以游离形式或盐形式，其制备，其医疗用途和包含它们的药物。
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Patent Agency Ranking
公开(公告)号：US20140256715A1
公开(公告)日：2014-09-11
申请号：US14350938
申请日：2012-10-11
Applicant: Konstanze Hurth , Sebastien Jacquier , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
Inventor： Konstanze Hurth , Sebastien Jacquier , Rainer Machauer , Heinrich Rueeger , Marina Tintelnot-Blomley , Siem Jacob Veenstra , Markus Voegtle
IPC: C07D265/30 , A61K31/5377 , C07D487/04 , A61K31/5375 , C07D471/04 , C07D417/12 , C07D413/12
CPC classification number: C07D265/30 , A61K31/5375 , A61K31/5377 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
Abstract translation: 本发明涉及式（I）的新的恶嗪衍生物及其药学上可接受的盐，其中所有变量如说明书，其药物组合物，其组合，及其作为药物的用途，特别是用于治疗 通过BACE-1或BACE-2的抑制来治疗阿尔茨海默病或糖尿病。
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7.发明申请Novel Heterocyclic Derivatives and Their Use in the Treatment of Neurological Disorders 有权新型杂环衍生物及其在神经障碍治疗中的应用公开(公告)号：US20140107118A1
公开(公告)日：2014-04-17
申请号：US14136855
申请日：2013-12-20
Applicant: Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sebastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
Inventor： Sangamesh BADIGER , Murali CHEBROLU , Konstanze HURTH , Sebastien JACQUIER , Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Marina TINTELNOT-BLOMLEY , Siem Jacob VEENSTRA , Markus VOEGTLE
IPC: C07D413/14 , C07D487/04 , C07D471/04 , A61K31/5377
CPC classification number: C07D413/14 , A61K31/5377 , C07B59/002 , C07B2200/05 , C07D471/04 , C07D487/04 , A61K2300/00
Abstract: The invention relates to novel heterocyclic compounds of the formula in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
Abstract translation: 本发明涉及下式的新型杂环化合物，其中所有变量如本说明书中所定义，其药物组合物，其组合及其作为药物的用途，特别是用于通过BACE-抑制剂的抑制治疗阿尔茨海默病或糖尿病， 1或BACE-2。
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公开(公告)号：US20130172331A1
公开(公告)日：2013-07-04
申请号：US13592580
申请日：2012-08-23
Applicant: Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Siem Jacob VEENSTRA
Inventor： Rainer Martin LUEOEND , Rainer MACHAUER , Heinrich RUEEGER , Siem Jacob VEENSTRA
IPC: C07D413/14 , A61K31/5355 , A61K45/06
CPC classification number: C07D413/14 , A61K31/5355 , A61K45/06
Abstract: The invention relates to novel oxazine derivatives of formula (I), and pharmaceutically acceptable salts thereof, in which all of the variables are as defined in the specification, pharmaceutical compositions thereof, combinations thereof, and their use as medicaments, particularly for the treatment of Alzheimer's Disease or diabetes via inhibition of BACE-1 or BACE-2.
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公开(公告)号：US08008250B2
公开(公告)日：2011-08-30
申请号：US11794412
申请日：2006-01-13
Applicant: Andreas Lerchner , Rainer Machauer , Marina Tintelnot-Blomley , Oliver Simic
Inventor： Andreas Lerchner , Rainer Machauer , Marina Tintelnot-Blomley , Oliver Simic
IPC: A61K31/551 , C07D243/00 , C07K7/50
CPC classification number: C07D273/02 , C07D245/06 , C07D291/08 , C07D413/04 , C07D413/12 , C07D419/12
Abstract: Macrocyclic compounds of the formula in which R1, R3, V1, V2, X1, X2, Y, Z, Ar, AA and n are as defined in the specification, the number of ring atoms included in the macrocyclic ring being 14, 15, 16, 17 or 18, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them are presented.
Abstract translation: R1，R3，V1，V2，X1，X2，Y，Z，Ar，AA和n如本说明书中所定义的下式的大环化合物，大环中包含的环原子数为14,15， 16,17或18，以游离碱形式或酸加成盐形式，其制备，用作药物和包含它们的药物。
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公开(公告)号：US20090029960A1
公开(公告)日：2009-01-29
申请号：US12159742
申请日：2006-12-28
Applicant: Claudia Betschart , Manuel Koller , Kurt Laumen , Andreas Lerchner , Rainer Machauer , Clive McCarthy , Marina Tintelnot-Blomley , Siem Jacob Veenstra
Inventor： Claudia Betschart , Manuel Koller , Kurt Laumen , Andreas Lerchner , Rainer Machauer , Clive McCarthy , Marina Tintelnot-Blomley , Siem Jacob Veenstra
IPC: A61K31/33 , C07D225/00 , A61P25/00
CPC classification number: C07D245/04 , C07D273/00
Abstract: The invention relates to novel macrocyclic compounds of the formula in which all of the variables are as defined in the specification, in free base form or in acid addition salt form, to their preparation, to their use as medicaments and to medicaments comprising them.
Abstract translation: 本发明涉及下式的新型大环化合物，其中所有变量如本说明书中所定义，游离碱形式或酸加成盐形式，其制备方法，用作药物和包含它们的药物。
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