发明授权
US08013163B2 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
有权
4-（2,6-二氯 - 苯甲酰氨基）-1H-吡唑-3-羧酸哌啶-4-基酰胺酸加成盐作为激酶抑制剂
- 专利标题： 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
- 专利标题（中）： 4-（2,6-二氯 - 苯甲酰氨基）-1H-吡唑-3-羧酸哌啶-4-基酰胺酸加成盐作为激酶抑制剂
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申请号： US11814458申请日： 2006-01-20
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公开(公告)号： US08013163B2公开(公告)日： 2011-09-06
- 发明人: Paul Graham Wyatt , David Charles Rees , Mladen Vinkovic , Gary Trewartha
- 申请人： Paul Graham Wyatt , David Charles Rees , Mladen Vinkovic , Gary Trewartha
- 申请人地址： GB Cambridge
- 专利权人： Astex Therapeutics Limited
- 当前专利权人： Astex Therapeutics Limited
- 当前专利权人地址： GB Cambridge
- 代理机构： Heslin Rothenberg Farley & Mesiti P.C.
- 优先权： GB0501475.8 20050122
- 国际申请： PCT/GB2006/000207 WO 20060120
- 国际公布： WO2006/077426 WO 20060727
- 主分类号： C07D401/00
- IPC分类号： C07D401/00 ; A61K31/445
摘要：
The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.
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