4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
    3.
    发明授权
    4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors 有权
    4-(2,6-二氯 - 苯甲酰氨基)-1H-吡唑-3-羧酸哌啶-4-基酰胺酸加成盐作为激酶抑制剂

    公开(公告)号:US08013163B2

    公开(公告)日:2011-09-06

    申请号:US11814458

    申请日:2006-01-20

    IPC分类号: C07D401/00 A61K31/445

    CPC分类号: C07D231/40 C07D401/12

    摘要: The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.

    摘要翻译: 本发明提供4-(2,6-二氯 - 苯甲酰基氨基)-1H-吡唑-3-羧酸哌啶-4-基酰胺及其晶体的酸加成盐,该盐由选自甲磺酸和乙酸的酸形成 酸及其混合物。 还提供了4-(2,6-二氯 - 苯甲酰基氨基)-1H-吡唑-3-羧酸哌啶-4-基酰胺的盐的新用途,制备4-(2,6-二氯 - 苯甲酰基氨基 )-1H-吡唑-3-羧酸哌啶-4-基酰胺及其盐和新的化学中间体。

    Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases
    4.
    发明授权
    Compositions comprising (S)-2-amino-1-(4-chlorophenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol as modulator of protein kinases 有权
    包含(S)-2-氨基-1-(4-氯苯基)-1- [4-(1H-吡唑-4-基) - 苯基] - 乙醇作为蛋白激酶调节剂的组合物

    公开(公告)号:US08497294B2

    公开(公告)日:2013-07-30

    申请号:US13180127

    申请日:2011-07-11

    IPC分类号: A61K31/415 C07D231/12

    摘要: The invention provides a composition comprising (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, wherein the composition is either substantially free of (R)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol or the composition contains a mixture of the (S) and (R) enantiomers in which the (S) enantiomer predominates. Also provided are processes for the preparation of the (S)2-amino-1-(4-chloro-phenyl)-1-[4-(1H-pyrazol-4-yl)-phenyl]-ethanol, novel process intermediates and methods for making the novel process intermediates.

    摘要翻译: 本发明提供包含(S)2-氨基-1-(4-氯 - 苯基)-1- [4-(1H-吡唑-4-基) - 苯基] - 乙醇的组合物,其中组合物基本上不含 的(R)2-氨基-1-(4-氯 - 苯基)-1- [4-(1H-吡唑-4-基) - 苯基] - 乙醇或该组合物含有(S)和( (S)对映异构体占优势。 还提供了制备(S)2-氨基-1-(4-氯 - 苯基)-1- [4-(1H-吡唑-4-基) - 苯基] - 乙醇的方法,新工艺中间体和 制备新工艺中间体的方法。

    4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors
    7.
    发明申请
    4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide acid addition salts as kinase inhibitors 有权
    4-(2,6-二氯 - 苯甲酰氨基)-1H-吡唑-3-羧酸哌啶-4-基酰胺酸加成盐作为激酶抑制剂

    公开(公告)号:US20090012124A1

    公开(公告)日:2009-01-08

    申请号:US11814458

    申请日:2006-01-20

    CPC分类号: C07D231/40 C07D401/12

    摘要: The invention provides an acid addition salt of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and crystals thereof, the salt being formed with an acid selected from methanesulphonic acid and acetic acid and mixtures thereof. Also provided are the novel uses of salts of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide, processes for the preparation of 4-(2,6-dichloro-benzoylamino)-1H-pyrazole-3-carboxylic acid piperidin-4-ylamide and its salts and novel chemical intermediates.

    摘要翻译: 本发明提供4-(2,6-二氯 - 苯甲酰基氨基)-1H-吡唑-3-羧酸哌啶-4-基酰胺及其晶体的酸加成盐,该盐由选自甲磺酸和乙酸的酸形成 酸及其混合物。 还提供了4-(2,6-二氯 - 苯甲酰基氨基)-1H-吡唑-3-羧酸哌啶-4-基酰胺的盐的新用途,制备4-(2,6-二氯 - 苯甲酰基氨基 )-1H-吡唑-3-羧酸哌啶-4-基酰胺及其盐和新的化学中间体。